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However, its role in lipopolysaccharide\u2010 (LPS\u2010)\/D\u2010galactosamine\u2010 (D\u2010GalN\u2010) induced ALF is still not investigated. Here, we established an ALF murine model induced by LPS\/D\u2010GalN administration. And we found that OI improved survival rate in the murine ALF model. Our results also showed that OI alleviated LPS\/D\u2010GalN\u2010induced hepatic histopathological injury and reduced the serum activities of alanine transaminase and aspartate transaminase. Moreover, OI reduced serum levels of proinflammatory cytokines such as monocyte chemotactic protein\u20101, tumor necrosis factors\u2010<jats:italic>\u03b1<\/jats:italic>, and interlukin\u20106. Additionally, OI mitigated oxidative stress and alleviated lipid peroxidation in a murine model of ALF. This was evaluated by a reduction of thiobarbituric acid reactive substances (TBARS) in liver tissues. In addition, OI increased the ratio of reduced glutathione\/oxidized glutathione and the activities of antioxidant enzymes including catalase and superoxide dismutase. Moreover, the apoptosis of hepatocytes in the liver was inhibited by OI. Furthermore, we found that OI inhibited LPS\u2010induced nuclear translocation and activation of factor\u2010kappa B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) p65 in macrophages which could be inhibited by OI\u2010induced activation of nuclear factor erythroid\u20102\u2010related factor (Nrf2) signaling. Additionally, D\u2010GalN\u2010induced reactive oxygen species (ROS) generation and apoptosis in hepatocytes were inhibited by OI\u2010induced activation of Nrf2 signaling. Therefore, the underlying mechanism for OI\u2019s protective effect in LPS\/D\u2010GalN\u2010induced ALF may be associated with deactivation of NF\u2010<jats:italic>\u03ba<\/jats:italic>B signaling in macrophages to reduce inflammation and inhibition of ROS\u2010related hepatocyte apoptosis by activating Nrf2. In conclusion, OI showed a protective role in LPS\/D\u2010GalN\u2010induced ALF by reducing inflammation, enhancing antioxidant capacity, and inhibiting cell apoptosis.<\/jats:p>","DOI":"10.1155\/2021\/9932099","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T19:51:28Z","timestamp":1629316288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Protective Role of 4\u2010Octyl Itaconate in Murine LPS\/D\u2010GalN\u2010Induced Acute Liver Failure via Inhibiting Inflammation, Oxidative Stress, and 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