{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:55:39Z","timestamp":1793404539948,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:p>Introduction. This network meta-analysis aimed to evaluate the efficacy and safety of different dual antiplatelet therapies (DAPTs) after percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods. Randomized controlled trials (RCTs) comparing longer-term (&gt;12 months) DAPT (L-DAPT), 12-month DAPT (DAPT 12Mo), 6-month DAPT (DAPT 6Mo), 3-month DAPT followed by aspirin monotherapy (DAPT 3Mo\u2009+\u2009ASA), 3-month DAPT followed by a P2Y12 receptor inhibitor monotherapy (DAPT 3Mo\u2009+\u2009P2Y12), or 1-month DAPT with a P2Y12 receptor inhibitor monotherapy (DAPT 1Mo\u2009+\u2009P2Y12) were searched. Primary endpoints were all-cause mortality, cardiac death, myocardial infarction (MI), major bleeding, any bleeding, definite or probable stent thrombosis (ST), and net adverse clinical events (NACE). This Bayesian network meta-analysis was performed with the random-effects model. Results. Twenty-four RCTs (n\u2009=\u200981339) were included. In comparison with L-DAPT, DAPT 6Mo (OR: 0.50, 95% CI: 0.29\u20130.83), DAPT 3Mo\u2009+\u2009P2Y12 (OR: 0.38, 95% CI: 0.18\u20130.82), DAPT 3Mo\u2009+\u2009ASA (OR: 0.44, 95% CI: 0.17\u20130.98), and DAPT 1Mo\u2009+\u2009P2Y12 (OR: 0.45, 95% CI: 0.14\u20130.93) were associated with a lower risk of major bleeding. DAPT 3Mo\u2009+\u2009P2Y12 (OR: 0.58, 95% CI: 0.38\u20130.88) reduced the risk of any bleeding when compared with DAPT 12Mo. L-DAPT decreased the risk of MI and definite or probable stent ST when compared with DAPT 6Mo. DAPT 3Mo\u2009+\u2009P2Y12 decreased the risk of NACE in comparison with DAPT 6Mo and DAPT 12Mo. No significant difference in all-cause mortality and cardiac death was observed. In patients with acute coronary syndrome, DAPT 6Mo was comparable to DAPT 12Mo. Conclusion. Short-term (1\u20133 months) DAPT is noninferior to DAPT 6Mo after DESs implantation, while L-DAPT reduces MI and definite or probable ST rates. DAPT 3Mo\u2009+\u2009P2Y12 might be a reasonable trade-off in patients with high risk of bleeding accompanied by ischemia.<\/jats:p>","DOI":"10.1155\/2021\/9934535","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T22:21:05Z","timestamp":1620339665000},"page":"1-12","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Dual Antiplatelet Therapy in Patients Undergoing Coronary Stent Implantation: A Systematic Review and Network Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3814-0506","authenticated-orcid":true,"given":"Yi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-734X","authenticated-orcid":true,"given":"Yimin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7313-2990","authenticated-orcid":true,"given":"Delong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-1571","authenticated-orcid":true,"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China"},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-9516","authenticated-orcid":true,"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000404"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx334"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2017.12.004"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz821"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7580"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.8145"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1908419"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.8146"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31858-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"12","article-title":"Cochrane handbook for systematic reviews of interventions version 6.1","author":"J. 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