{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:47:05Z","timestamp":1782564425682,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2021,7,9]]},"abstract":"<jats:p>We relay the case of a teenage female with severe facial acne vulgaris and a past psychiatric history of major depressive disorder who presented to the emergency department with a primary complaint of ongoing suicidal ideation. Defining features of this case stem from the patient endorsing that her suicidal ideation was a result of her severe acne and the coinciding social perturbation it caused. Additionally, the patient reported that just four months prior to the current presentation, her dermatologist started her on isotretinoin therapy for the management of acne vulgaris. To the best of the authors\u2019 knowledge, there have been no reported cases which describe a teenage female presenting with active suicidal ideation secondary to severe acne vulgaris while concurrently undergoing treatment with isotretinoin. Given the controversial but reported association between isotretinoin and increased suicidality, we considered the appropriateness of continuing this medication for our patient. We then conducted a literature search evaluating the evidence concerning this association. In what follows, we present a unique case report and provide a thorough review of the evidence\u2014or lack thereof\u2014surrounding the relationship between isotretinoin and suicidality. Additionally, the authors aim to provide recommendations for the management of future patients who may present under similar circumstances.<\/jats:p>","DOI":"10.1155\/2021\/9942327","type":"journal-article","created":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T00:05:06Z","timestamp":1625961906000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Isotretinoin in Acne Vulgaris Complicated by Underlying Major Depression: A Case Report and Review of Literature"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-8292","authenticated-orcid":true,"given":"Matthew","family":"DeLuca","sequence":"first","affiliation":[{"name":"St. George\u2019s University School of Medicine, True Blue, WI, Grenada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7581-3725","authenticated-orcid":true,"given":"Maxsaya Baez","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"St. George\u2019s University School of Medicine, True Blue, WI, Grenada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2523-1919","authenticated-orcid":true,"given":"Ezequiel","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"St. George\u2019s University School of Medicine, True Blue, WI, Grenada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2488-6515","authenticated-orcid":true,"given":"Krishan","family":"Chirimunj","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bergen New Bridge Medical Center, 230 E Ridgewood Ave, Paramus, NJ 07652, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10r05993"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.3.9364"},{"key":"3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000246018","article-title":"Oral isotretinoin treatment policy. Do we all agree?","volume":"195","author":"J. P. Ortonne","year":"1997","journal-title":"Dermatology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v5.i2.222"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05334.x"},{"issue":"511","key":"6","first-page":"134","article-title":"Isotretinoin, depression and suicide: a review of the evidence","volume":"55","author":"M. Parker","year":"2005","journal-title":"British Journal of General Practice"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz093"},{"issue":"1","key":"8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.31887\/DCNS.2011.13.1\/ccelano","article-title":"Depressogenic effects of medications: a review","volume":"13","author":"C. M. 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Cohen","year":"2007","journal-title":"The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2005.05.008"},{"issue":"5","key":"17","first-page":"557","article-title":"Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study","volume":"141","author":"C. Y. Chia","year":"2005","journal-title":"Archives of dermatology"},{"key":"18","first-page":"341","article-title":"Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study","volume":"12","author":"A. Sundstr\u00f6m","year":"2010","journal-title":"BMJ"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03806.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.11.006"},{"key":"21","first-page":"712","article-title":"Psychosocial effect of common skin diseases","volume":"48","author":"B. 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