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Agarwood has been used for centuries, especially for treatment of gastrointestinal diseases. Earlier studies of our laboratory suggested that agarwood alcohol extracts (AAEs) provided gastric mucosal protection. This study aims to investigate the ameliorative effect of AAEs on ethanol-induced gastric ulcers and its mechanism. Methods. Mice were given agarwood induced by the whole-tree agarwood-inducing technique alcohol extract (WTAAE, 0.71, 1.42, and 2.84\u2009g\/kg), wild agarwood induced by axe wounds alcohol extract (WAAE, 2.84\u2009g\/kg), and burning-chisel-drilling agarwood alcohol extract (FBAAE, 2.84\u2009g\/kg) orally, respectively. After 7 days\u2019 pretreatment with AAEs, the gastric ulcers were induced by absolute ethanol. The ulcer index, gastric histopathology, biochemical parameters, and inflammatory proteins were evaluated. Results. Pharmacological results showed AAEs (1.42 and 2.84\u2009g\/kg) reduced the gastric occurrence and ulcer inhibition rates up to more than 60%. AAEs decreased the level of nitric oxide (NO) and increased glutathione (GSH) and superoxide dismutase (SOD) levels. Besides, AAEs decreased the levels of interleukin-1\u03b2 (IL-1\u03b2) and interleukin-6 (IL-6), but the interleukin-10 (IL-10) was upregulated. The expressions of nuclear factor kappa B (NF-\u03baB) and phosphorylated protein 38 (p-P38) were inhibited. The effect of WTAAE was better than that of FBAAE and similar to that of WAAE at the dose of 2.84\u2009g\/kg. Conclusions. These results demonstrate that agarwood alleviates the occurrence and development of gastric ulcers via inhibiting oxidation and inflammation.<\/jats:p>","DOI":"10.1155\/2021\/9944685","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T22:05:06Z","timestamp":1632002706000},"page":"1-11","source":"Crossref","is-referenced-by-count":11,"title":["Agarwood Alcohol Extract Protects against Gastric Ulcer by Inhibiting Oxidation and Inflammation"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8106-2638","authenticated-orcid":true,"given":"Canhong","family":"Wang","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqian","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hainan Medical College, Haikou 571199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Wu","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China"},{"name":"School of Pharmacy, Hainan Medical College, Haikou 571199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8049-8675","authenticated-orcid":true,"given":"Peng","family":"Guo","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China"},{"name":"National Engineering Laboratory for Breeding of Endangered Medicinal Materials and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9168-5812","authenticated-orcid":true,"given":"Jianhe","family":"Wei","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China"},{"name":"National Engineering Laboratory for Breeding of Endangered Medicinal Materials and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18033086"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(88)90138-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.100122"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201100077"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.07.011"},{"issue":"3","key":"6","first-page":"187","article-title":"Protective effect of agarwood alcohol extracts produced by whole-tree agarwood-inducing technique on the Fluorouracil -induced liver injury in mice","volume":"45","author":"C. 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