{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:44:43Z","timestamp":1790628283821,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["9905072861"],"award-info":[{"award-number":["9905072861"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2021,6,22]]},"abstract":"<jats:p>Introduction. Chronic inflammation and oxidative stress conditions have been reported in women with polycystic ovary syndrome (PCOS). Peroxiredoxin 4 (Prx4) is a related antioxidant in insulin synthesis. We hypothesized that insulin resistance in these women is associated with total oxidant status (TOS) and inflammatory factors. Materials and Methods. Two hundred three people including 104 PCOS patients and 99 healthy women, who were matched for age and body mass index (BMI), entered the study. Waist circumference of the participants was measured; serum glucose, lipid profile, insulin, Prx4, TOS, hs-CRP, and TNF-\u03b1 were also evaluated. Results. The Prx4 level was significantly lower in PCOS than in the control group. In addition, marked increase was observed in the concentration of TOS, hs-CRP, and TNF-\u03b1 in PCOS, compared to the healthy women. There was a positive correlation of TOS with hs-CRP, TNF-\u03b1, and HOMA-IR. The risk of PCOS for subjects with high hs-CRP was 60 times greater than those who had low serum hs-CRP concentration; after performing multiple logistic regression analyses with the backward method, TNF-\u03b1 was considered as an effective biomarker to predict PCOS \u03b2\u2009=\u200949.087 (all <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Conclusion. This study identified increased oxidative stress and inflammation in PCOS; this may be due to decrease in the antioxidants, such as Prx4.<\/jats:p>","DOI":"10.1155\/2021\/9949753","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T20:05:05Z","timestamp":1624392305000},"page":"1-8","source":"Crossref","is-referenced-by-count":16,"title":["Association of Prx4, Total Oxidant Status, and Inflammatory Factors with Insulin Resistance in Polycystic Ovary Syndrome"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-759X","authenticated-orcid":true,"given":"Sahar","family":"Mazloomi","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"},{"name":"Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-3917","authenticated-orcid":true,"given":"Nasrin","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-3270","authenticated-orcid":true,"given":"Marzieh","family":"Sanoee Farimani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medicine School, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2639-2941","authenticated-orcid":true,"given":"Shamim","family":"Pilehvari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medicine School, Hamadan University of Medical Sciences, Hamadan, Iran"},{"name":"Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoz042"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.03.008"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2008.05.004"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000109523.25076.e2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29912"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18062923"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121971"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00075"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00404-020-05951-2","article-title":"Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update","volume":"303","author":"S. 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