{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:21:27Z","timestamp":1763706087880,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2021,7,16]]},"abstract":"<jats:p>Background. Angioimmunoblastic T cell lymphoma (AITL) is an aggressive Epstein\u2013Barr virus-associated T cell lymphoma. Clinical syndromes of AITL are not confined to fever and lymphadenopathy, and patients may initially present with polyclonal plasma cell proliferation, which may obscure the underlying disease of AITL, delaying diagnosis. Case Presentation. Here, we report two AITL patients with excessive plasma cell proliferation in the bone marrow, peripheral blood, and ascites even mimicking plasma cell leukemia. Both of them had poor endings. Conclusions. Our report emphasizes the complexity of the clinical manifestations of AITL, which aims to increase the alertness of physicians and improve the rate of early diagnosis. Integrated diagnostic approaches such as histopathology, flow cytometry, cytogenetics, and molecular biology are essential for accurate diagnosis and precise therapy.<\/jats:p>","DOI":"10.1155\/2021\/9951122","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T02:35:10Z","timestamp":1626489310000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["The Early Diagnostic Dilemma in Angioimmunoblastic T Cell Lymphoma with Excessive Plasma Cells Proliferation"],"prefix":"10.1155","volume":"2021","author":[{"given":"Chunyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Clincal Trial and Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0242-1987","authenticated-orcid":true,"given":"Xia","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Clincal Trial and Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songya","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Clincal Trial and Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Clincal Trial and Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Clincal Trial and Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Clincal Trial and Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Demonstration Center for Environmental and Planning, College of Environment & Planning, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Clincal Trial and Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-07-1708"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-055145"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.37.3647"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v51.1.71.71"},{"key":"5","first-page":"407","article-title":"Angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin","volume-title":"WHO classi\ufb01cation of Tumours of Haematopoietic and Lymphoid Tissues. Revised","author":"A. Dogan","year":"2017","edition":"4th ed."},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2016.1170827"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404013"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2080"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13393"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.357"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-531509"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0990-y"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.11.029"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1996.14.2.593"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07042.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00509"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1411-z"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6121"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2018.03.014"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-017-0824-x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3189-1"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06577.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.126300"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-105759"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-374371"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1459610"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2019.1668720"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6157"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/nri1714"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.09.009"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v94.2.701.414k16_701_712"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.79.2.1296-1307.2005"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2742"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/9951122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/9951122.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/9951122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T02:35:14Z","timestamp":1626489314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crim\/2021\/9951122\/"}},"subtitle":[],"editor":[{"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":33,"alternative-id":["9951122","9951122"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9951122","relation":{},"ISSN":["1687-9635","1687-9627"],"issn-type":[{"type":"electronic","value":"1687-9635"},{"type":"print","value":"1687-9627"}],"subject":[],"published":{"date-parts":[[2021,7,16]]}}}