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The pathophysiology of functional dyspepsia (FD) remains uncertain, but the interstitial cells of Cajal (ICCs), pacemakers that regulate gastrointestinal motility, are garnering attention as key modulators and therapeutic targets in FD. This review comprehensively discusses the involvement of ICCs in the pharmacologic actions of FD and as therapeutic targets for herbal products for FD. Methods. A search of the literature was performed using PubMed by pairing \u201cinterstitial cells of Cajal\u201d with \u201cmedicinal plant, herbal medicine, phytotherapy, flavonoids, or traditional Chinese medicine (TCM).\u201d Results. From the 55 articles screened in the initial survey, 34 articles met our study criteria. The search results showed that herbal products can directly depolarize ICCs to generate pacemaker potentials and increase the expression of c-kit and stem cell factors, helping to repair ICCs. Under certain pathological conditions, medicinal plants also protect ICCs from oxidative stress and\/or inflammation-induced impairment. Two representative herbal decoctions (Banhasasim-tang, \u534a\u590f\u6cfb\u5fc3\u6c64, and Yukgunja-tang, \u516d\u541b\u5b50\u6c64) have been shown to modulate ICC functions by both clinical and preclinical data. Conclusion. This review strongly indicates the potential of herbal products to target ICCs and suggests that further ICC-based studies would be promising for the development of FD treatment agents.<\/jats:p>","DOI":"10.1155\/2021\/9952691","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T22:35:09Z","timestamp":1625092509000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-7048","authenticated-orcid":true,"given":"Jin-Yong","family":"Joung","sequence":"first","affiliation":[{"name":"Liver and Immunology Research Center, Oriental Medical College of Daejeon University, 75, Daedeok-daero 176 beon-gil, Seo-gu, Daejeon 35235, Republic of 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