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Necrostatin-1 (Nec-1), an inhibitor of necroptosis, has been reported to protect against myocardial ischemia-reperfusion (MI\/R) injury. However, the contribution of the potential antinecroptotic effect of Nec-1 on its infarct limitation and cardiac function improvement effects after MI\/R has not been investigated. Methods. The present study investigated the effect of Nec-1 on myocardial infarct size, necroptosis, and cardiac functional recovery in rats subjected to myocardial ischemia-reperfusion (MI\/R 30\u2009min\/12, 24, 48, and 72\u2009h). Results. The study showed that Nec-1 might reduce myocardial cell death and maintain myoarchitectonic integrity, consequently inhibiting the reactive fibrosis process in rats in myocardial ischemia\/late reperfusion. Moreover, the administration of Nec-1 (0.6\u2009mg\/kg) at the onset of reperfusion significantly reduced the release of creatine kinase and downregulation of autophagy within 24\u2009h after reperfusion, and there was a significantly positive correlation between them. Conclusion. These results suggest that antinecroptosis treatment may improve the clinical outcomes of patients with ischemic heart disease.<\/jats:p>","DOI":"10.1155\/2021\/9956814","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T18:11:28Z","timestamp":1626199888000},"page":"1-8","source":"Crossref","is-referenced-by-count":14,"title":["Cardioprotective Effect of Nec-1 in Rats Subjected to MI\/R: Downregulation of Autophagy-Like Cell Death"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-2758","authenticated-orcid":true,"given":"Liang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Peking University International Hospital, Beijing 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebai","family":"Lv","sequence":"additional","affiliation":[{"name":"Third Medical Center, The General Hospital of the People's Liberation Army, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Physiology, Shanxi Medical University, Taiyuan 030001, China"},{"name":"Department of Pathophysiology, Ningxia Medical University, Yinchuan, Ningxia 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Shanxi Medical University, Taiyuan 030001, China"},{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100029, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Disease, Capital Medical University, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2881-6074","authenticated-orcid":true,"given":"Hui Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Shanxi Medical University, Taiyuan 030001, China"},{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100029, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Disease, Capital Medical University, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001571"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.12.012"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2007.00262.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.788"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.4.371"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1023\/B:APPT.0000038035.75845.ab"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.088203"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00935.2003"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3582006pe44"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096645"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511288103"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio711"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00290-5"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401777"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0406-y"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400852"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506843102"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.11.2787"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603783200"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.14670\/HH-17.897"},{"key":"22","first-page":"453","article-title":"Autophagy in cardiac myocytes","volume":"12","author":"H. 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