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Recent studies have shown that the abnormal expression of TTF\u20101 is closely related to the occurrence of a variety of human diseases and can be used as a potential new target for the diagnosis and treatment of related diseases. In this article, in order to strengthen the systematic understanding of TTF\u20101 and promote the progress of related research, we reviewed the structure, expression regulation, biological functions of TTF\u20101, and its role in the occurrence and development of human\u2010related clinical diseases. Meanwhile, we prospect the future research direction of TTF\u20101, which might ultimately contribute to the understanding of the pathogenesis of related clinical diseases and the development of new prevention and treatment strategies.<\/jats:p>","DOI":"10.1155\/2021\/9957209","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T18:38:44Z","timestamp":1632940724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Thyroid Transcription Factor\u20101: Structure, Expression, Function and Its Relationship with Disease"],"prefix":"10.1155","volume":"2021","author":[{"given":"Lian","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-9368","authenticated-orcid":false,"given":"Xu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-9649","authenticated-orcid":false,"given":"Lin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-8083","authenticated-orcid":false,"given":"Juanjuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-9220","authenticated-orcid":false,"given":"Ya","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-0279","authenticated-orcid":false,"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2017.05.007"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_1404_16"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07574.x"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08391.x"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb16571.x"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.7.12.8145764"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.14.8108"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00007-1"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3290395"},{"key":"e_1_2_14_10_2","first-page":"30","article-title":"Temporal expression of thyroid transcription factor-1 in fetal and neonatal human lungs","volume":"8","author":"Kong X. 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