{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:29:42Z","timestamp":1772836182819,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":166,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ruhr University Bochum","award":["K133-19"],"award-info":[{"award-number":["K133-19"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Acute appendicitis (AA) might be amenable to conservative antibiotic treatment, whereas a perforated appendix (PA) necessitates surgery. We investigated the value of clinical\u2013laboratory markers in distinguishing AA from a PA. <jats:italic>Methods<\/jats:italic>. Retrospectively obtained preoperative parameters for 306 consecutive patients (&lt;18 years) with histologically confirmed appendicitis (AA (<jats:italic>n<\/jats:italic> = 237) <jats:italic>vs<\/jats:italic>. PA (<jats:italic>n<\/jats:italic> = 69)), treated at our institution between January 2014 and December 2017. <jats:italic>Results<\/jats:italic>. A PA was associated with male preponderance, younger age, decreased sodium level and increased white blood cell count, Tzanakis score, C\u2010reactive protein (CRP) level, and CRP\u2010to\u2010lymphocyte ratio (CLR). Upon discrimination analysis, CLR and CRP displayed the highest accuracy in differentiating a PA from AA. Regression analysis identified levels of CRP, sodium, and the Tzanakis score as independent predictors for a PA. <jats:italic>Conclusion<\/jats:italic>. Levels of CLR, CRP, sodium, and Tzanakis score might support decision\u2010making regarding treatment options for pediatric appendicitis.<\/jats:p>","DOI":"10.1155\/2021\/9957829","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T16:50:07Z","timestamp":1623862207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Levels of C\u2010Reactive Protein and Sodium May Differentiate a Perforated Appendix from a Nonperforated Appendix in Children"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-8127","authenticated-orcid":false,"given":"M.","family":"Nissen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-5584","authenticated-orcid":false,"given":"R.-B.","family":"Tr\u00f6bs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115734"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2012.10.003"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817841"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-017-0335-2"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200006000-00005"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-020-04620-4"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2019.175"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.105658"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-7853-6"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.32893"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-005-0545-8"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/children8040309"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.09.066"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00275-5"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000256391.05233.aa"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10888"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.08.051"},{"key":"e_1_2_12_18_2","first-page":"57","article-title":"Experiences with LESS-appendectomy in children","volume":"19","author":"Vahdad M. 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