{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:06:59Z","timestamp":1768626419403,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":266,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>The study is aimed at observing the influence of microribonucleic acid\u2010 (miRNA\u2010) 30a\u201050p on the pulmonary fibrosis in mice with Streptococcus pneumoniae infection through the regulation of autophagy by Beclin\u20101. Specific pathogen\u2010free mice were instilled with Streptococcus pneumoniae through the trachea to establish the pulmonary fibrosis model. Then, they were divided into the miRNA\u201030a\u201050p mimics group (mimics group, <jats:italic>n<\/jats:italic> = 10) and miRNA\u201030a\u20105p inhibitors group (inhibitors group, <jats:italic>n<\/jats:italic> = 10), with the control group (<jats:italic>n<\/jats:italic> = 10) also set. Pulmonary tissue wet weight\/dry weight (W\/D) was detected. The content of tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>), interleukin\u2010 (IL\u2010) 6, and myeloperoxidase (MPO) was determined using enzyme\u2010linked immunosorbent assay (ELISA). Besides, the changes in the pulmonary function index dynamic lung compliance (Cdyn), plateau pressure (Pplat), and peak airway pressure (Ppeak) were monitored, and the gene and protein expression levels were measured via quantitative PCR (qPCR) and Western blotting. The expression level of miRNA\u201030a\u20105p was substantially raised in the mimics group (<jats:italic>p<\/jats:italic> &lt; 0.05), but extremely low in the inhibitors group (<jats:italic>p<\/jats:italic> &lt; 0.05). The mimics group had obviously raised levels of serum aminotransferase (AST), glutamic\u2010pyruvic transaminase (GPT), alkaline phosphatase (ALP), and pulmonary tissue W\/D (<jats:italic>p<\/jats:italic> &lt; 0.05). Additionally, the expression levels of TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20106, and MPO were notably elevated in the mimics group, while their expression levels showed the opposite conditions in the inhibitors group (<jats:italic>p<\/jats:italic> &lt; 0.05). According to the HE staining results, the inhibitors group had arranged orderly cells, while the mimics group exhibited lung injury, pulmonary edema, severe inflammatory response, and alveolar congestion. In the inhibitors group, Cdyn was remarkably elevated, but Pplat and Ppeak declined considerably (<jats:italic>p<\/jats:italic> &lt; 0.05). Besides, the inhibitors group exhibited elevated messenger RNA (mRNA) levels of Beclin\u20101 and LC3, lowered mRNA levels of <jats:italic>\u03b1<\/jats:italic>\u2010SMA and p62, a raised protein level of Beclin\u20101, and a markedly decreased protein level of p62 (<jats:italic>p<\/jats:italic> &lt; 0.05). Silencing miRNA\u201030a\u20105p expression can promote the expression of Beclin\u20101 to accelerate the occurrence of autophagy, thereby treating pulmonary fibrosis in mice with Streptococcus pneumoniae infection.<\/jats:p>","DOI":"10.1155\/2021\/9963700","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T19:19:27Z","timestamp":1632511167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["[Retracted] Influence of miRNA\u201030a\u20105p on Pulmonary Fibrosis in Mice with Streptococcus pneumoniae Infection through Regulation of Autophagy by Beclin\u20101"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-8296","authenticated-orcid":false,"given":"Hanyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yabo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingdong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingzong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongfei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050062"},{"key":"e_1_2_8_2_2","first-page":"S27","article-title":"Idiopathic pulmonary fibrosis. 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