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In the present study, we explored the effects of myricetin on alcohol-induced gastric ulcer in a rat model. To induce gastric ulcer, absolute ethanol (5\u2009mL\/kg body weight) was orally administrated to each rat. The positive control and myricetin-treated groups were given oral doses of omeprazole (20\u2009mg\/kg) or myricetin (12\u2009mg\/kg), respectively, 1 hour prior to the administration of absolute alcohol. We found that pretreatment with myricetin significantly decreased alcohol-induced gastric ulcer, hemorrhage, hyperemia, and epithelial cell loss in the gastric mucosa. Myricetin pretreatment reduced the level of malondialdehyde (MDA) and increased that of total glutathione (GSSG\/GSH) and superoxide dismutase (SOD) in gastric tissues. In addition, it elevated the expression levels of cyclooxygenase-1 (COX-1) and prostaglandin E2 (PGE2) and decreased the phosphorylation of nuclear factor kappa B (NF-\u03baB). Together, these results indicate that myricetin effectively inhibits ethanol-induced acute gastric injury by preventing oxidative damage, stimulating PGE2 production, and inhibiting NF-\u03baB activation. We suggest that myricetin may be an alternative treatment for gastric injury caused by alcohol intake.<\/jats:p>","DOI":"10.1155\/2021\/9968112","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T21:35:43Z","timestamp":1633037743000},"page":"1-9","source":"Crossref","is-referenced-by-count":24,"title":["Gastroprotective Effect of Myricetin on Ethanol-Induced Acute Gastric Injury in Rats"],"prefix":"10.1155","volume":"2021","author":[{"given":"Hee-seon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Seob","family":"Seo","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun 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