{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:44:58Z","timestamp":1766486698445,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2021,7,28]]},"abstract":"<jats:p>Objective. Evaluation of the pruritus features in children with end-stage renal disease (ESRD) who underwent dialysis at an academic tertiary pediatric dialysis center. Methods. This cross-sectional study was conducted at an academic tertiary pediatric dialysis center, Isfahan, Iran. The reviewed medical records of the children included their characteristics, dialysis properties, and laboratory parameters. The 4-item itch questionnaire was utilized to assess distribution, severity, frequency, and associated sleeping disorders. Results. Thirty ESRD patients with pruritus, including 23 males (76.7%) with a mean age of <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>11.7<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>3.64<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> years, were recruited. The most common cause of CKD was nephronophthisis (23.3%). The median total score of pruritus was 5 (range: 3-15). The distribution score of pruritus was directly correlated with the age (Spearman\u2019s <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>rho<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>.42, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.02<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and serum level of parathyroid hormone (PTH) (Spearman\u2019s <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mtext>rho<\/g:mtext>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.42<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.04<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). In the reduced multiple logistic regression model, the increasing level of serum calcium was associated with increased odds of having <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mtext>total<\/k:mtext>\n                        <k:mtext>\u2009<\/k:mtext>\n                        <k:mtext>pruritus<\/k:mtext>\n                        <k:mtext>\u2009<\/k:mtext>\n                        <k:mtext>score<\/k:mtext>\n                        <k:mo>\u2265<\/k:mo>\n                        <k:mn>5<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula> (OR (odds ratio): 4.5; 95% CI 1.12 to 18.05). In addition, an increase in age for one year was found to be associated with 50% higher odds of having <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>total<\/m:mtext>\n                        <m:mtext>\u2009<\/m:mtext>\n                        <m:mtext>pruritus<\/m:mtext>\n                        <m:mtext>\u2009<\/m:mtext>\n                        <m:mtext>score<\/m:mtext>\n                        <m:mo>\u2265<\/m:mo>\n                        <m:mn>5<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula> (OR: 1.5; 95% CI 1.03 to 2.18). Conclusion. Increased level of serum Ca and higher age were associated with increased odds of having more severe pruritus score in children.<\/jats:p>","DOI":"10.1155\/2021\/9970321","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T21:35:09Z","timestamp":1627508109000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Pruritus Features in Children with End-Stage Renal Disease Underwent Dialysis: A Cross-Sectional Study"],"prefix":"10.1155","volume":"2021","author":[{"given":"Mehryar","family":"Mehrkash","sequence":"first","affiliation":[{"name":"Imam Hossein Children\u2019s Hospital and Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed-javad","family":"Golestaneh","sequence":"additional","affiliation":[{"name":"School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahya","family":"Madihi","sequence":"additional","affiliation":[{"name":"Imam Hossein Children\u2019s Hospital and Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Paknazar","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Hadian","sequence":"additional","affiliation":[{"name":"School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Akbari","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1081-9477","authenticated-orcid":true,"given":"Bahareh","family":"Abtahi-Naeini","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children\u2019s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00399"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.06.025"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2932-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.265453"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02592.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh480"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2020.10.013"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5256"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246765"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.9.1558"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000010633"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000251"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl461"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1159\/000145461"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04466.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05490610"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.0142-5463.2004.00199.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02478-2"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027092"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2012.01109.x"},{"key":"21","first-page":"19","article-title":"Uremic pruritus; its prevalence, pathophysiology and management","volume-title":"Intech Open Sci","author":"P. Aramwit","year":"2015"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1995.tb01328.x"},{"issue":"7","key":"23","first-page":"670","article-title":"Uraemic pruritus and plasma histamine concentrations","volume":"8","author":"V. Piazza","year":"1993","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"1","key":"24","first-page":"86","article-title":"Factors associated with pruritus uremic in chronic kidney failure patients","volume":"30","author":"A. Harlim","year":"2020","journal-title":"Journal of Pakistan Association of Dermatology"}],"container-title":["International Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2021\/9970321.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2021\/9970321.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2021\/9970321.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T21:35:12Z","timestamp":1627508112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijpedi\/2021\/9970321\/"}},"subtitle":[],"editor":[{"given":"Lavjay","family":"Butani","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":24,"alternative-id":["9970321","9970321"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9970321","relation":{},"ISSN":["1687-9759","1687-9740"],"issn-type":[{"type":"electronic","value":"1687-9759"},{"type":"print","value":"1687-9740"}],"subject":[],"published":{"date-parts":[[2021,7,28]]}}}