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To compare redox imbalance and inflammation biomarkers in umbilical cords from pregnancies with and without preeclampsia (PE) and to analyse their relationships with perinatal outcomes. <jats:italic>Methods<\/jats:italic>. A controlled cross\u2010sectional study was conducted in Macei\u00f3, Alagoas, Brazil, that involved pregnant women with PE and a group of women without the disease, through the application of a standardized questionnaire. After delivery, umbilical cord samples were collected to measure antioxidant defense, products from oxidative damage, and inflammation biomarkers such as myeloperoxidase (MPO), interleukin\u2010 (IL\u2010) 6, IL\u20108, IL\u201010, and tumor necrosis factor\u2010alpha (TNF\u2010<jats:italic>\u03b1<\/jats:italic>). Statistical analyses were performed using Stata version 13.0 software and IBM Statistical Package for the Social Sciences (SPSS) 20.0, adopting a 95% confidence level (<jats:italic>\u03b1<\/jats:italic> = 0.05), with the chi\u2010square test, the Wilcoxon\u2013Mann\u2013Whitney test, and the multinomial and Poisson regression tests. <jats:italic>Results<\/jats:italic>. One hundred PE pregnant women and 50 women without the disease were studied. The umbilical cords from PE pregnancies showed higher levels of reduced glutathione (GSH) (<jats:italic>p<\/jats:italic> \u2264 0.001), glutathione peroxidase (GPx) (<jats:italic>p<\/jats:italic> = 0.016), and malondialdehyde (MDA) (<jats:italic>p<\/jats:italic> = 0.028) and lower levels of IL\u20106 (<jats:italic>p<\/jats:italic> = 0.030) and TNF\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:italic>p<\/jats:italic> \u2264 0.001) than the other group, with some associations among these biomarkers with perinatal outcomes. <jats:italic>Conclusion<\/jats:italic>. The higher levels of GSH and GPx, in addition to the lower levels of IL\u20106 and TNF\u2010<jats:italic>\u03b1<\/jats:italic>, found in the PE umbilical cord, may result from adaptive mechanisms to maintain the oxidative and inflammatory balance; however, despite these changes, the damage to the cell membranes was not minimized, as the MDA level was higher in women with PE than in women without the disease. This implies that a redox imbalance is present, confirming that other physiological and adaptive mechanisms are being activated to preserve foetal health. Therefore, the present work unveils an important role of the umbilical cord in controlling redox imbalance and inflammation in PE pregnancies. Our results reinforce the necessity for continuous research on GSH as a protective compound for the perinatal outcome, especially in PE women.<\/jats:p>","DOI":"10.1155\/2021\/9970627","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T02:50:47Z","timestamp":1636512647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Biomarkers of Inflammation and Redox Imbalance in Umbilical Cord in Pregnancies with and without Preeclampsia and Consequent Perinatal Outcomes"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-0491","authenticated-orcid":false,"given":"Marilene Brand\u00e3o Ten\u00f3rio","family":"Fragoso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1613-8819","authenticated-orcid":false,"given":"Raphaela Costa","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-489X","authenticated-orcid":false,"given":"Micaely Cristina dos Santos","family":"Ten\u00f3rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-0193","authenticated-orcid":false,"given":"Fabiana Andr\u00e9a","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-6520","authenticated-orcid":false,"given":"Orlando Roberto Pimentel","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-0297","authenticated-orcid":false,"given":"Nassib Bezerra","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-3667","authenticated-orcid":false,"given":"Mar\u00edlia Oliveira Fonseca","family":"Goulart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-919X","authenticated-orcid":false,"given":"Alane Cabral Menezes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3548917"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16-0492"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.5812\/iranjradiol.12230v2"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.02.024"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00470-X"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-017-0641-1"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194814"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.09.014"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8238727"},{"key":"e_1_2_9_10_2","first-page":"1","article-title":"Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia","volume":"1866","author":"Marin R.","year":"2020","journal-title":"BBA-Molecular Basis of Disease"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.36.2.1316"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108464"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4393460"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_161_18"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200208000-00018"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.10.024"},{"key":"e_1_2_9_17_2","first-page":"501","article-title":"Pre-eclampsia-associated alterations in Wharton\u2019s jelly proteoglycans","volume":"52","author":"Gogiel T.","year":"2005","journal-title":"Acta Biochimica Polonica"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00296-1"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-16814108"},{"key":"e_1_2_9_20_2","volume-title":"Case Control Studies","author":"Tenny S.","year":"2020"},{"key":"e_1_2_9_21_2","volume-title":"Epidemiology of Study Design","author":"Munnangi S.","year":"2020"},{"key":"e_1_2_9_22_2","first-page":"1122","article-title":"Hypertension in pregnancy. 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