{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:57:00Z","timestamp":1788785820329,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:p>Objective. This study aimed to investigate the efficacy of acupoint injection for alleviating side effects of chemotherapy in people with cancer. Methods. PubMed, EMBASE, Cochrane library databases, CNKI, VIP, WanFang Date, and CBM were searched for randomized controlled trials (RCTs) from inception through December 28, 2020. This meta-analysis was performed using Review Manager 5.3. Results. A total of 8 RCTs including 557 participants were eligible and included in the meta-analysis. The selected RCTs studied acupoint injection for alleviating side effects of chemotherapy in people with cancer. Statistically significant improvements were observed for the incidence of nausea and vomiting (RR\u2009=\u20090.39; 95% CI 0.26, 0.58; <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.00001), the number of leukocyte (MD\u2009=\u20091.89; 95%CI 0.74, 3.03; <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009=\u20090.001), and the number of platelet (MD\u2009=\u200928.82; 95%CI 19.33, 38.30; <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.00001). Two of these studies suggested that acupoint injection can also reduce some other adverse reactions, which showed a statistical difference (RR\u2009=\u20090.29; 95% CI 0.11, 0.75; <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009=\u20090.01). Conclusion. The analysis indicated that acupoint injection can alleviate side effects of chemotherapy in people with cancer. However, due to the high risk of bias and small sample size in the included studies, the results need to be further confirmed by further large, rigorously designed trials.<\/jats:p>","DOI":"10.1155\/2021\/9974315","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T21:20:23Z","timestamp":1622236823000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Acupoint Injection for Alleviating Side Effects of Chemotherapy in People with Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-6425","authenticated-orcid":true,"given":"Yulan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Acupuncture, Maoming People\u2019s Hospital, Maoming, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Maoming People\u2019s Hospital, Maoming, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Maoming People\u2019s Hospital, Maoming, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Maoming People\u2019s Hospital, Maoming, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30382"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2698-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1039\/c8dt00838h"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184360"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.17925\/ohr.2011.07.2.91"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"7","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"J. P. T. Higgins","year":"2017"},{"key":"8","article-title":"Chapter 8: assessing risk of bias in included studies","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version5.2.0","author":"J. P. T. Higgins","year":"2017"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"issue":"1","key":"11","first-page":"12","article-title":"Clinical study on preventing the virulent and side-effect of malignant tumor due to chemotherapy by acu-mox","volume":"20","author":"Y. Fan","year":"2001","journal-title":"Shanghai Journal Acu-Mox"},{"issue":"8","key":"12","first-page":"1094","article-title":"Clinical study on effects of prevention and treatment of Shenfu injection zusanli acupoint injection to the virulent and side-effect caused by tomor chemotherapy","volume":"44","author":"F. Ma","year":"2016","journal-title":"Modern Medical Journal"},{"key":"13","volume-title":"The Observation of the Clinical Therapeutic Effect of Acupoint Injecting Astragalus Injection on the Adverse Reaction of Chemotherapy in Patients with Gastric Cancer","author":"F. J. Nan","year":"2014"},{"issue":"19","key":"14","first-page":"2590","article-title":"Clinical analysis of acupoint injection in the treatment of nausea, vomiting and myelosuppression in patients with cisplatin chemotherapy","volume":"27","author":"Q. Wu","year":"2014","journal-title":"Medical Theory and Practice"},{"issue":"20","key":"15","first-page":"1858","article-title":"Effects of droperidol acupoint injection on response to chemotherapy and survival quality of lung cancer patients","volume":"24","author":"Y. M. 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Yang","year":"2008","journal-title":"China Journal of Modem Medicine"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6054-x"},{"key":"20","volume-title":"Cancer Treatment and Survivorship Facts & Figures 2014\u20132015","author":"American Cancer Society","year":"2018"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3768-7"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2.6.597"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3119-2"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/9974315.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/9974315.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/9974315.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T21:20:34Z","timestamp":1622236834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/9974315\/"}},"subtitle":[],"editor":[{"given":"Amin","family":"Tamadon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":23,"alternative-id":["9974315","9974315"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9974315","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,28]]}}}