{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:26:43Z","timestamp":1784752003465,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":146,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["3755"],"award-info":[{"award-number":["3755"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. In the recent decade, the increased immunocompromised population such as diabetic patients makes a high incidence of invasive <jats:italic>Candida<\/jats:italic> infections. Diabetes mellitus is the most common endocrine metabolic disorder, and diabetic patients are more susceptible to oral candidiasis infection. Candidiasis is an opportunistic fungal infection caused by many species of <jats:italic>Candida<\/jats:italic>. Secretion of exoenzymes plays an important role in the virulence and pathogenesis of <jats:italic>Candida<\/jats:italic> species. The aim of this study was to evaluate the potential role of phospholipase, esterase, and hemolytic activity of <jats:italic>Candida<\/jats:italic> species isolated from oral cavity lesions of diabetic patients. <jats:italic>Methods<\/jats:italic>. A total of 108 <jats:italic>Candida<\/jats:italic> species including 75 <jats:italic>Candida albicans<\/jats:italic> and 33 non\u2010<jats:italic>Candida albicans<\/jats:italic> species were recovered from the oral cavity of diabetic patients included in our study. Egg yolk agar, Tween 80 opacity medium, and blood agar plate assays were used for determining phospholipase, esterase, and hemolytic activities, respectively. <jats:italic>Results<\/jats:italic>. <jats:italic>Candida albicans<\/jats:italic> species had the most exoenzyme activity in comparison to non<jats:italic>-albicans<\/jats:italic> isolates. <jats:italic>Candida albicans<\/jats:italic> isolates showed 97.3%, 100%, and 77.3% phospholipase, hemolysin, and esterase activities, respectively. The difference between <jats:italic>Candida albicans<\/jats:italic> and non\u2010<jats:italic>Candida albicans<\/jats:italic> was significant in phospholipase (<jats:italic>P<\/jats:italic> &lt; 0.001) and hemolytic activity (<jats:italic>P<\/jats:italic> = 0.027), but not significant in esterase activity (<jats:italic>P<\/jats:italic> = 0.076). <jats:italic>Conclusion<\/jats:italic>. This study showed that most of the isolates had different enzymatic patterns, and <jats:italic>Candida albicans<\/jats:italic> isolates had the most exoenzyme activity. So due to the potential effects of these enzymes in pathogenesis and virulence effects of <jats:italic>Candida<\/jats:italic> species, we can conclude that the severity of extracellular enzymes may play a role in the severity of signs and symptoms of <jats:italic>Candida<\/jats:italic> oral cavity infections in diabetic patients.<\/jats:p>","DOI":"10.1155\/2021\/9982744","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T19:38:32Z","timestamp":1622144312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Potential Pathogenicity of <i>Candida<\/i> Species Isolated from Oral Cavity of Patients with Diabetes Mellitus"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-5357","authenticated-orcid":false,"given":"Hasti","family":"Nouraei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi 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