{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:37:28Z","timestamp":1772131048807,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":241,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>The aim of the present study was to investigate the ameliorative potential of parsley (<jats:italic>Petroselinum crispum<\/jats:italic>) leaf essential oil (PO) against the detrimental effects of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) on the thyroid gland and testes of mice. Twenty\u2010four adult male mice were divided into four groups and treated for 4 weeks. The 1<jats:sup>st<\/jats:sup> control group received 3\u2009mL\/kg olive oil intraperitoneally, twice a week followed by 0.5\u2009mL\/kg saline intragastrically daily. The 2<jats:sup>nd<\/jats:sup> CCl<jats:sub>4<\/jats:sub> group received CCl<jats:sub>4<\/jats:sub> (3\u2009mL\/kg intraperitoneally, twice a week). The 3<jats:sup>rd<\/jats:sup> PO group received PO (0.5\u2009mL\/kg intragastrically daily), while the 4<jats:sup>th<\/jats:sup> CCl<jats:sub>4<\/jats:sub>+PO group received CCl<jats:sub>4<\/jats:sub> coadministrated with PO at the aforementioned doses. CCl<jats:sub>4<\/jats:sub> group recorded significant (<jats:italic>p<\/jats:italic> &lt; 0.05) reduction in the activities of antioxidant enzyme catalase (CAT) and superoxide dismutase (SOD) and significant (<jats:italic>p<\/jats:italic> &lt; 0.05) increase in the lipid peroxidation end product\u2019s level malondialdehyde (MDA) in the testes and thyroid glands. Meanwhile, serum levels of testosterone, follicle\u2010stimulating hormone (FSH), luteinizing hormone (LH), and thyroid hormones (thyroid\u2010stimulating hormone (TSH), total triiodothyronine (T3), free triiodothyronine (fT3), total thyroxine (T4), and free thyroxine (fT4)) significantly decreased. Also, histopathologically, the testicular tissue showed hypospermatogenesis within irregular\u2010shaped seminiferous tubules with prominent edema in the interstitial spaces confirming the aforementioned biochemical alterations. Treatment with PO significantly reduced the testicular and thyroid oxidative stress (<jats:italic>p<\/jats:italic> &lt; 0.05) and elevated the testosterone (73.47%), FSH (92.11%), LH (33.33%), T3 (23.47%), fT3 (39.13%), T4 (27.91%), and fT4 (75%) as compared to that of CCl<jats:sub>4<\/jats:sub>\u2010treated group corresponding values. The PO GC\/MS analysis indicated bioactive monoterpenes (major component is 1,3,8\u2010mentha triene 34.48%) and phenylpropenes (major component is myristicin 21.04%). Results suggested the ameliorative effect of PO against CCl<jats:sub>4<\/jats:sub>\u2010induced hypogonadism in mice by suppressing oxidative stress and maintaining thyroid gland function.<\/jats:p>","DOI":"10.1155\/2021\/9989174","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T23:50:08Z","timestamp":1630367408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Antioxidant Potential of Parsley Leaf (<i>Petroselinum crispum<\/i>) Essential Oil on Hypothyroidism and Testicular Injury in Mice Intoxicated by Carbon Tetrachloride"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2745-0362","authenticated-orcid":false,"given":"Gehan M.","family":"Badr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmohsen I.","family":"Algefare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7426-6811","authenticated-orcid":false,"given":"Manal A.","family":"Alfwuaires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.1.1.6843"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.617843"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.3.4.12858"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.005132"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410x.1990.tb14715.x"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei429"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-86502007000100005"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.190555"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.9.559"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.857"},{"key":"e_1_2_10_12_2","first-page":"338","article-title":"Effect of T3 treatment on glutathione redox pool and its metabolizing enzymes in mitochondrial and post-mitochondrial fractions of adult rat testes","volume":"45","author":"Sahoo D. 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