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Currently, there is no reliable nonsurgical treatment for abdominal aortic aneurysm (AAA). This study, therefore, investigates if doxycycline reduces AAA growth and the number of rupture-related deaths in a murine ApoE\u2212\/\u2212 model of AAA and whether gadofosveset trisodium-based MRI differs between animals with and without doxycycline treatment. Methods. Nine ApoE\u2212\/\u2212 mice were implanted with osmotic minipumps continuously releasing angiotensin II and treated with doxycycline (30\u2009mg\/kg\/d) in parallel. After four weeks, MRI was performed at 3T with a clinical dose of the albumin-binding probe gadofosveset (0.03\u2009mmol\/kg). Results were compared with previously published wild-type control animals and with previously studied ApoE\u2212\/\u2212 animals without doxycycline treatment. Differences in mortality were also investigated between these groups. Results. In a previous study, we found that approximately 25% of angiotensin II-infused ApoE\u2212\/\u2212 mice died, whereas in the present study, only one out of 9 angiotensin II-infused and doxycycline-treated ApoE\u2212\/\u2212 mice (11.1%) died within 4 weeks. Furthermore, doxycycline-treated ApoE\u2212\/\u2212 mice showed significantly lower contrast-to-noise (CNR) values (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.017<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) in MRI compared to ApoE\u2212\/\u2212 mice without doxycycline treatment. In vivo measurements of relative signal enhancement (CNR) correlated significantly with ex vivo measurements of albumin staining (R2\u2009=\u20090.58). In addition, a strong visual colocalization of albumin-positive areas in the fluorescence albumin staining with gadolinium distribution in LA-ICP-MS was shown. However, no significant difference in aneurysm size was observed after doxycycline treatment. Conclusion. The present experimental in vivo study suggests that doxycycline treatment may reduce rupture-related deaths in AAA by slowing endothelial damage without reversing aneurysm growth.<\/jats:p>","DOI":"10.1155\/2021\/9999847","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T21:11:23Z","timestamp":1619644283000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Doxycycline on Survival in Abdominal Aortic Aneurysms in a Mouse Model"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-0172","authenticated-orcid":true,"given":"Lisa C.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Radiology, Charite\u0301-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Charit\u00e9platz 1, Berlin 10117, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5533-8004","authenticated-orcid":true,"given":"Julia","family":"Brangsch","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charite\u0301-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Charit\u00e9platz 1, Berlin 10117, Germany"},{"name":"Department of Veterinary Medicine, Institute of Veterinary Pathology, Freie Universit\u00e4t Berlin, Robert-von-Ostertag-Str. 15, Building 12, Berlin 14163, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7687-7840","authenticated-orcid":true,"given":"Jan O.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charite\u0301-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Charit\u00e9platz 1, Berlin 10117, 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