{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:45:09Z","timestamp":1790887509419,"version":"4.1.0"},"reference-count":90,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2021R1A2C1008564"],"award-info":[{"award-number":["2021R1A2C1008564"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,10,3]]},"abstract":"<jats:p>Convolvulus pluricaulis (CP), a Medhya Rasayana (nootropic) herb, is a major ingredient in Ayurvedic and Traditional Chinese formulae indicated for neurological conditions, namely, dementia, anxiety, depression, insanity, and epilepsy. Experimental evidence suggests various neuroactive potentials of CP such as memory-enhancing, neuroprotective, and antiepileptic. However, precise mechanisms underlying the neuropharmacological effects of CP remain unclear. The study, therefore, aimed at deciphering the molecular basis of neuroprotective effects of CP phytochemicals against the pathology of dementia disorders such as Alzheimer\u2019s (AD) and Parkinson\u2019s (PD) disease. The study exploited bioinformatics tools and resources, such as Cytoscape, DAVID (Database for annotation, visualization, and integrated discovery), NetworkAnalyst, and KEGG (Kyoto Encyclopedia of Genes and Genomes) database to investigate the interaction between CP compounds and molecular targets. An in silico analysis was also employed to screen druglike compounds and validate some selective interactions. ADME (absorption, distribution, metabolism, and excretion) analysis predicted a total of five druglike phytochemicals from CP constituents, namely, scopoletin, 4-hydroxycinnamic acid, kaempferol, quercetin, and ayapanin. In network analysis, these compounds were found to interact with some molecular targets such as prostaglandin G\/H synthase 1 and 2 (PTGS1 and PTGS2), endothelial nitric oxide synthase (NOS3), insulin receptor (INSR), heme oxygenase 1 (HMOX1), acetylcholinesterase (ACHE), peroxisome proliferator-activated receptor-gamma (PPARG), and monoamine oxidase A and B (MAOA and MAOB) that are associated with neuronal growth, survival, and activity. Docking simulation further confirmed interaction patterns and binding affinity of selected CP compounds with those molecular targets. Notably, scopoletin showed the highest binding affinity with PTGS1, NOS3, PPARG, ACHE, MAOA, MAOB, and TRKB, quercetin with PTGS2, 4-hydroxycinnamic acid with INSR, and ayapanin with HMOX1. The findings indicate that scopoletin, kaempferol, quercetin, 4-hydroxycinnamic acid, and ayapanin are the main active constituents of CP which might account for its memory enhancement and neuroprotective effects and that target proteins such as PTGS1, PTGS2, NOS3, PPARG, ACHE, MAOA, MAOB, INSR, HMOX1, and TRKB could be druggable targets against dementia.<\/jats:p>","DOI":"10.1155\/2022\/1015310","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T18:50:06Z","timestamp":1664823006000},"page":"1-18","source":"Crossref","is-referenced-by-count":23,"title":["Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-4495","authenticated-orcid":true,"given":"Md. Abdul","family":"Hannan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Sultana","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-3149","authenticated-orcid":true,"given":"Md. Hasanur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering, Faculty of Life Sciences, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Al Mamun Sohag","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-3255","authenticated-orcid":true,"given":"Md Jamal","family":"Uddin","sequence":"additional","affiliation":[{"name":"ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh"},{"name":"Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-5898","authenticated-orcid":true,"given":"Muhammad Jahangir","family":"Hossen","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Patuakhali Science and Technology University, Dumki, Patuakhali 8602, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-016X","authenticated-orcid":true,"given":"Il Soo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105011"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00443"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s2221-1691(14)60240-9"},{"issue":"1","key":"4","first-page":"19","article-title":"Review on ethnomedicinal uses and phytopharmacology of memory boosting herb Convolvulus pluricaulis Choisy","volume":"22","author":"N. K. Sethiya","year":"2010","journal-title":"Australian Journal of Medical Herbalism"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6540"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00171"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1970"},{"key":"8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/WNR.0000000000001446","article-title":"Convolvulus pluricaulis extract can modulate synaptic plasticity in rat brain hippocampus","volume":"31","author":"R. Das","year":"2020","journal-title":"NeuroReport"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2011.584539"},{"issue":"1","key":"10","first-page":"616","article-title":"Comparative nootropic effect of Evolvulus alsinoides and Convolvulus pluricaulis","volume":"2","author":"P. Kothiyal","year":"2011","journal-title":"International Journal of Pharma Bio Sciences"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2017.08.012"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.84958"},{"issue":"5","key":"13","first-page":"479","article-title":"Effect of Convolvulus pluricaulis Choisy and Asparagus racemosus willd on learning and memory in young and old mice: a comparative evaluation","volume":"48","author":"K. Sharma","year":"2010","journal-title":"Indian Journal of Experimental Biology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2017.11.002"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.05.038"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.100383"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2017.10.002"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02942-8"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1025398"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112393"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2021.13.33"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2020.06.011"},{"issue":"2","key":"23","first-page":"21","article-title":"Protective effects of some natural and synthetic antidepressants against chronic fatigue induced alterations","volume":"3","author":"Y. Sahu","year":"2011","journal-title":"Journal of Global Pharma Technology"},{"key":"24","first-page":"262","article-title":"Screening for antidepressant-like activity of convolvulus pluricaulis choisy in mice","volume":"1","author":"D. Dhingra","year":"2007","journal-title":"Pharmacologyonline"},{"issue":"7","key":"25","first-page":"BR155","article-title":"Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests","volume":"13","author":"D. Dhingra","year":"2007","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2174\/187152412800229161"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.046"},{"issue":"2","key":"28","first-page":"349","article-title":"Antistress potential of convolvulus pluricaulis choisy in chronic cold swimming stress rat model","volume":"9","author":"K. Yuvaraj Babu","year":"2018","journal-title":"International Journal of Research in Pharmacy and Science"},{"issue":"2","key":"29","first-page":"353","article-title":"Effect of convolvulus pluricaulis aqueous extract on behavioural changes and antioxidants in stress induced rats","volume":"9","author":"K. Yuvaraj Babu","year":"2018","journal-title":"International Journal of Research in Pharmacy and Science"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3390\/md17110639"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.2174\/1871527319999200730214807"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj161"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw943"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.092"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.052"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3711"},{"key":"40","volume-title":"LigPrep","author":"L. J. L. Schr\u00f6dinger","year":"2017"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-007-9133-z"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.7324\/japs.2015.501112"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409005102"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0588-5"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-409x(96)00423-1"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-409x(02)00008-x"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666161117112604"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21372"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1039\/c4cp01378f"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.4103\/0973-8258.142666"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2986796"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.01.027"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24122287"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.09.008"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.565700"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.2174\/1871527320666210129122033"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2020.98199"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10010"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1177\/2633105520937693"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.577790"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103293"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1159\/000505731"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.06.019"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1038\/srep42995"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00116"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55364-8"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913572107"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00643-5"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108352"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205068"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00830"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww117"},{"key":"73","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa109","article-title":"Anti-inflammatories in Alzheimer\u2019s disease\u2014potential therapy or spurious correlate?","volume":"2","author":"J. Rivers-Auty","year":"2020","journal-title":"Brain Communications"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.12.046"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4620"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8508491"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00180"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12182"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.309686"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-018-1524-2"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24101"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-016-0211-9"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00340"},{"key":"84","article-title":"Selegiline for Alzheimer\u2019s disease","volume":"1","author":"J. Birks","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2012-120013"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0436-1"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.588516"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5268-11.2012"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/753587"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9121914"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/1015310.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/1015310.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/1015310.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T18:50:20Z","timestamp":1664823020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/1015310\/"}},"subtitle":[],"editor":[{"given":"Muhammad Furqan","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,3]]},"references-count":90,"alternative-id":["1015310","1015310"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1015310","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,3]]}}}