{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:21:50Z","timestamp":1781522510400,"version":"3.54.1"},"reference-count":85,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":312,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MB108"],"award-info":[{"award-number":["ZR2020MB108"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MH063"],"award-info":[{"award-number":["ZR2019MH063"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018684","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["2017ZX09301064"],"award-info":[{"award-number":["2017ZX09301064"]}],"id":[{"id":"10.13039\/501100018684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018684","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["2017ZX09301064002"],"award-info":[{"award-number":["2017ZX09301064002"]}],"id":[{"id":"10.13039\/501100018684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874419"],"award-info":[{"award-number":["81874419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673719"],"award-info":[{"award-number":["81673719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81303074"],"award-info":[{"award-number":["81303074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Depression is a serious psychological disorder with a rapidly increasing incidence in recent years. Clinically, selective serotonin reuptake inhibitors are the main therapy. These drugs, have serious adverse reactions, however. Traditional Chinese medicine has the characteristics of multiple components, targets, and pathways, which has huge potential advantages for the treatment of depression. The antidepressant potential of the herbal combination of Bupleurum chinense DC (Chaihu) and Paeonia lactiflora Pall (Baishao) has been extensively studied previously. In this review, we summarized the antidepressant active components and mechanism of Chaihu\u2010Baishao herb pair. We found that it works mainly through relieving oxidative stress, regulating HPA axis, and protecting neurons. Nevertheless, current research of this combined preparation still faces many challenges. On one hand, most of the current studies only stay at the level of animal models, lacking of sufficient clinical double\u2010blind controlled trials for further verification. In addition, studies on the synergistic effect between different targets and signaling pathways are scarce. On the other hand, this preparation has numerous defects such as poor stability, low solubility, and difficulty in crossing the blood\u2010brain barrier.<\/jats:p>","DOI":"10.1155\/2022\/1024693","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T17:05:26Z","timestamp":1668013526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Antidepressant Active Components of Bupleurum chinense DC\u2010Paeonia lactiflora Pall Herb Pair: Pharmacological Mechanisms"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0607-7028","authenticated-orcid":false,"given":"Shimeng","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-5479","authenticated-orcid":false,"given":"Yifan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-4996","authenticated-orcid":false,"given":"Le","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-6251","authenticated-orcid":false,"given":"Yihong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-9109","authenticated-orcid":false,"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-5941","authenticated-orcid":false,"given":"Yufei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3130-1733","authenticated-orcid":false,"given":"Geqin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5149-9994","authenticated-orcid":false,"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-7685","authenticated-orcid":false,"given":"Dezhong","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6114-138X","authenticated-orcid":false,"given":"Yuexiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-4165","authenticated-orcid":false,"given":"Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104520"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.619288"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01121-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.917695"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108616"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-9-21"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02343-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113281"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x14666151208113700"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.12.005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.09.025"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.12032\/TMR20210616237"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0474-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.3090"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X14500797"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106181"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a00165"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.01.008"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030167"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.07.003"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-0389-5"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.08.044"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2017.07.006"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.02.007"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8050248"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110505"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.015"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02144-5"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114046"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2021.25.3.217"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14160"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.149"},{"key":"e_1_2_6_33_2","first-page":"1779","article-title":"Changes of chemical composition of Bupleuri radix-Paeoniae radix Alba herb pair before and after compatibility by UPLC-MS background subtraction and metabonomics","volume":"49","author":"He J.","year":"2018","journal-title":"Zhong Cao Yao"},{"key":"e_1_2_6_34_2","first-page":"13","article-title":"Research progress of Sini powder and prediction analysis on Q-markers","volume":"39","author":"Wu H. W.","year":"2021","journal-title":"Zhong Hua Zhong Yi Yao Xue."},{"key":"e_1_2_6_35_2","first-page":"22","article-title":"Effect of Sinisan on NLRP3 inflammasomes and depression-like behaviors in depressed rats","volume":"28","author":"Wang W.","year":"2022","journal-title":"Zhong Guo Shi Yan Fang Ji Xue Za Zhi"},{"key":"e_1_2_6_36_2","first-page":"1097","article-title":"Effects of Jiawei Sini powder on the levels of plasma IL-1\u03b2, IL-18, Hcy and neural factors in patients with depression after acute cerebral infarction","volume":"32","author":"Rao K. H.","year":"2021","journal-title":"Shi Zhen Guo Yi Guo Yao"},{"key":"e_1_2_6_37_2","first-page":"763","article-title":"Clinical observation on Sini powder combined with Gan Mai Dazao decoction in the treatment of type 2 diabetes mellitus complicated with depression and anxiety","volume":"39","author":"Zhang Q.","year":"2022","journal-title":"Guang Zhou Zhong Yi Yao Da Xue Xue Bao"},{"key":"e_1_2_6_38_2","first-page":"39","article-title":"Observation on the curative effect of Sini powder in the treatment of functional dyspepsia with depression","volume":"41","author":"Huang X. Y.","year":"2022","journal-title":"Nei Meng Gu Zhong Yi Yao"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.12.003"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153669"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.04.024"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.09.046"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4720-8"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-1008-y"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-017-2325-6"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030493"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.05.078"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2153571"},{"key":"e_1_2_6_49_2","first-page":"5103","article-title":"Paeoniflorin improves menopause depression in ovariectomized rats under chronic unpredictable mild stress","volume":"8","author":"Huang H.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-016-9922-y"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0152-y"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14695"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0748-5518"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933776"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200405000-00011"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00432-1"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.09.023"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00401-8"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.10.034"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0491-9"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7260130"},{"key":"e_1_2_6_62_2","first-page":"458","article-title":"Dose-effect relationship of Chaihu and Baishao on improving depression and diarrhea in patients with colorectal cancer surgery","volume":"27","author":"Mx H.","year":"2021","journal-title":"Zhong Guo Zhong Xi Yi Jie He Wai Ke Za Zhi"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.30"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.10.052"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.11.009"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.85"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146885"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113138"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2017"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2011.11.005"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02889"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00516"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.05.027"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.04.058"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051769"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105795"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01544"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1113\/EP088605"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.12.003"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2019.1576361"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00772"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4050"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-05257-5"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin.2019.01.116"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04097"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/1024693.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/1024693.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/1024693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T08:33:17Z","timestamp":1735633997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/1024693"}},"subtitle":[],"editor":[{"given":"Si","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/1024693"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1024693","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1024693"}}