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The alteration of bacterial proteins, enzymatic degradation, and change of membrane permeability towards antimicrobial agents are the key mechanisms of antimicrobial resistance. Based on the current condition, there is an urgent clinical need to develop new drugs to treat these bacterial infections. In the current study, the binding patterns of selected antimicrobial peptides (AMPs) with different multidrug\u2010resistant bacterial strains have been analyzed. Among ten selected AMPs in this study, napin and snakin\u20101 exhibited the best scores and binding patterns. Napin exhibited strong interactions with penicillin\u2010binding protein 1a of <jats:italic>Acinetobacter baumannii<\/jats:italic> (with a binding score of \u2010158.7\u2009kcal\/mol and ten hydrogen bonds), with glucose\u20101\u2010phosphate thymidylyltransferase of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> H37Rv (with a binding score of \u2010107.8\u2009kcal\/mol and twelve hydrogen bonds), and with streptomycin 3\u2009<jats:sup>\u2033<\/jats:sup>\u2010adenylyltransferase protein of <jats:italic>Salmonella enterica<\/jats:italic> (with a binding score of \u201084.2\u2009kcal\/mol and four hydrogen bonds). Similarly, snakin\u20101 showed strong interactions with oxygen\u2010insensitive NADPH nitroreductase of <jats:italic>Helicobacter pylori<\/jats:italic> (with a binding score of \u2010105.0\u2009kcal\/mol and thirteen hydrogen bonds) and with penicillin\u2010binding protein 2a of methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (with a binding score of \u2010103.8\u2009kcal\/mol and twenty\u2010three hydrogen bonds). The docking results were further validated by molecular dynamics simulations. The results of this computational approach support the evidence of efficiency of these AMPs as potent inhibitors of these specific proteins of bacterial strains. However, further validations are required to fully evaluate the potential of selected AMPs as drug candidates against these resistant bacterial strains.<\/jats:p>","DOI":"10.1155\/2022\/1077814","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T20:50:08Z","timestamp":1647895808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Investigation of Plant Antimicrobial Peptides against Selected Pathogenic Bacterial Species Using a Peptide\u2010Protein Docking Approach"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-6496","authenticated-orcid":false,"given":"Ghulam","family":"Mustafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6664-1543","authenticated-orcid":false,"given":"Hafiza Salaha","family":"Mahrosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-8792","authenticated-orcid":false,"given":"Khalid","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03035"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00194"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/102129"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2012.05338.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11240-019-01668-6"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph8040711"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-5792-6"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/1574892814666190119165157"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-013-0280-4"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep35465"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3591"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9110747"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19021672"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5561129"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.2174\/09298665113209990066"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/jms.jms_25_17"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.09.014"},{"key":"e_1_2_9_18_2","unstructured":"DeLanoW. 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