{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:03:09Z","timestamp":1773799389489,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":151,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>We aim to investigate the therapeutic effect of self\u2010made <jats:italic>Hewei<\/jats:italic> decoction based on the differences\u2010in\u2010differences (DID) model for treating chronic atrophic gastritis and its effect on the gastrin and pepsinogen expression. A total of 166 chronic atrophic gastritis patients treated in our hospital from January 2019 to September 2020 were recruited and randomly assigned to a treatment group and a control group (<jats:italic>n<\/jats:italic>\u2009=\u200983 per group). In the control group, patients were given conventional western medicine. In the treatment group, patients were administered self\u2010made <jats:italic>Hewei<\/jats:italic> decoction besides conventional western medicine. The general data, total effective rate, and histological changes before and after treatment were compared between the two groups. The DID model was utilized to compare the changes in three items of gastric function and traditional Chinese medicine (TCM) syndrome scores at various time points (before treatment and 1, 3, 6, and 12\u2009months after treatment) between the two groups. In the treatment group, 5 cases were lost to follow\u2010up, and 78 cases remained. In the control group, 4 cases were lost to follow\u2010up, and 79 cases remained. The total effective rate in the treatment group (93.59%) was significantly higher than that in the control group (82.28%) (<jats:italic>P<\/jats:italic> &lt; 0.05). The histological score was not significantly different between the two groups before treatment (<jats:italic>P<\/jats:italic> &gt; 0.05). The histological score at 12 months after treatment was lower than those before treatment in the two groups (<jats:italic>P<\/jats:italic> &lt; 0.05). The histological score was lower in the treatment group than that in the control group (<jats:italic>P<\/jats:italic> &lt; 0.05). After treatment, the TCM syndrome score and PGR17 level were lower in the treatment group than those in the control group at each time point (<jats:italic>P<\/jats:italic> &lt; 0.05). PGI and PGII levels were higher in the treatment group than those in the control group at each time point (<jats:italic>P<\/jats:italic> &lt; 0.05). DID regression model showed that TCM syndrome score and PGR17 level decreased by 106.2% and 65.8%, respectively, after treatment in patients with chronic atrophic gastritis (<jats:italic>P<\/jats:italic> &lt; 0.05), but the treatment mode was opposite to the overall therapeutic effect in terms of time. The PGI and PGII levels increased by 102.9% and 97.8%, respectively, in patients with chronic atrophic gastritis (<jats:italic>P<\/jats:italic> &lt; 0.05), and the treatment mode was the same as the overall therapeutic effect in terms of time. There was no significant difference in the therapeutic effect between the two groups at 1\u2009month after treatment. A significant difference in the therapeutic effect was detected between the two groups at 3\u2009months after treatment, and the difference showed a decreasing trend after 6\u2009months after treatment. Self\u2010made <jats:italic>Hewei<\/jats:italic> decoction can improve the histological alterations in chronic atrophic gastritis, relieve clinical symptoms, and ameliorate the expression levels of three items of gastric function.<\/jats:p>","DOI":"10.1155\/2022\/1092695","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T18:05:31Z","timestamp":1654106731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["[Retracted] Efficacy of Self\u2010Made Hewei Decoction for Chronic Atrophic Gastritis and Its Effect on Gastrin and Pepsinogen Expression Levels"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jianyun","family":"Ou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-0274","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10310"},{"key":"e_1_2_8_2_2","first-page":"1","article-title":"Effect of Anwei Decoction on the expression of ULK1-related autophagy protein in rats with chronic atrophic gastritis","volume":"7","author":"Zhou R.","year":"2021","journal-title":"Zhonghua Zhongyiyao Xuekan"},{"key":"e_1_2_8_3_2","first-page":"109","article-title":"Effect of Jianpi Qingre Huashi Decoction on traditional Chinese medicine syndrome score, atrophy score, PGI and PGII for patients with spleen-stomach dampness-heat type chronic atrophic gastritis","volume":"39","author":"Gan X.","year":"2021","journal-title":"Sichuan Zhongyi"},{"key":"e_1_2_8_4_2","first-page":"154","article-title":"Evaluation of clinical efficacy of soothing liver and regulating qi in the treatment of chronic atrophic gastritis with syndrome of disharmony of liver and stomach based on narrowband imaging-magnification endoscopy technology","volume":"18","author":"Li Li","year":"2021","journal-title":"Zhongguo Yiyao Daobao"},{"key":"e_1_2_8_5_2","first-page":"1","article-title":"The influence of TCM syndromes, histology and curative effect on acupuncture combined with additive Xiangsha Liujunzi Decoction the treatment for chronic atrophic gastritis of spleen-stomach deficiency pattern","volume":"11","author":"Wu C.","year":"2021","journal-title":"Zhonghua Zhongyiyao Xuekan"},{"key":"e_1_2_8_6_2","first-page":"106","article-title":"Clinical observation on Modified Banxia Xiexin Decoction in the treatment of chronic atrophic gastritis based on syndrome differentiation","volume":"20","author":"Pan X.","year":"2022","journal-title":"Zhongguo Zhongyiyao Xiandai Yuancheng Jiaoyu"},{"key":"e_1_2_8_7_2","first-page":"24","article-title":"Consensus on chronic gastritis in China","volume":"18","author":"Fang J.","year":"2013","journal-title":"Wei Chang Bing Xue"},{"key":"e_1_2_8_8_2","first-page":"330","article-title":"Investigation and analysis of syndromes of internal organs in guideline for clinical trials of New patent Chinese medicines","volume":"14","author":"Liang M.","year":"2008","journal-title":"Zhongguo Zhongyi Jichu Yixue Zazhi"},{"key":"e_1_2_8_9_2","first-page":"172","article-title":"Diagnosis and treatment plan of integrated traditional Chinese and western medicine for chronic gastritis (draft)","author":"Zhang W.","year":"2003","journal-title":"National Symposium on digestive system diseases of China Society of integrated traditional Chinese and Western Medicine"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-021-00445-y"},{"key":"e_1_2_8_11_2","first-page":"867","article-title":"Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis","volume":"39","author":"Bai Y.","year":"2019","journal-title":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan"},{"key":"e_1_2_8_12_2","unstructured":"LiuJ. 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