{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:17:19Z","timestamp":1772727439640,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":174,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070291"],"award-info":[{"award-number":["82070291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870183"],"award-info":[{"award-number":["81870183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170266"],"award-info":[{"award-number":["82170266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>The precise control of cardiomyocyte viability is imperative to combat myocardial ischemia\u2010reperfusion injury (I\/R), in which apoptosis and pyroptosis putatively contribute to the process. Recent researches indicated that GSDMD is involved in I\/R as an executive protein of pyroptosis. However, its effect on other forms of cell death is unclear. We identified that GSDMD and GSDMD\u2010N levels were significantly upregulated in the I\/R myocardium of mice. Knockout of GSDMD conferred the resistance of the hearts to reperfusion injury in the acute phase of I\/R but aggravated reperfusion injury in the chronic phase of I\/R. Mechanistically, GSDMD deficiency induced the activation of PARylation and the consumption of NAD<jats:sup>+<\/jats:sup> and ATP, leading to cardiomyocyte apoptosis. Moreover, PJ34, a putative PARP\u20101 inhibitor, reduced the myocardial injury caused by GSDMD deficiency. Our results reveal a novel action modality of GSDMD in the regulation of cardiomyocyte death; inhibition of GSDMD activates PARylation, suggesting the multidirectional role of GSDMD in I\/R and providing a new theory for clinical treatment.<\/jats:p>","DOI":"10.1155\/2022\/1115749","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T23:05:08Z","timestamp":1656111908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inhibition of GSDMD Activates Poly(ADP\u2010ribosyl)ation and Promotes Myocardial Ischemia\u2010Reperfusion Injury"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-2303","authenticated-orcid":false,"given":"Zheng-hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-4828","authenticated-orcid":false,"given":"Zi-guan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-0165","authenticated-orcid":false,"given":"Min-wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-5792","authenticated-orcid":false,"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-0110","authenticated-orcid":false,"given":"Run-jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9778-8193","authenticated-orcid":false,"given":"Jia-jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4275-6354","authenticated-orcid":false,"given":"Cui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-5850","authenticated-orcid":false,"given":"Yu-ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-7295","authenticated-orcid":false,"given":"Hong-wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-5146","authenticated-orcid":false,"given":"Shi-xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2953-4287","authenticated-orcid":false,"given":"Yan-ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-1932","authenticated-orcid":false,"given":"Ping","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-4646","authenticated-orcid":false,"given":"Yi-jiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-9435","authenticated-orcid":false,"given":"Wen-bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3638-3640","authenticated-orcid":false,"given":"Zhong-gui","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-9321","authenticated-orcid":false,"given":"Zheng-rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.10.009"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307855"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666191105103417"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2007"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0726-3"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4017"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-020-0790-6"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000717"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2019.11.019"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.139"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0415-z"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00404-4"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10174"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.04.010"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17664"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-018-9462-2"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.100"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.318629"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8405370"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165768"},{"key":"e_1_2_9_23_2","first-page":"86","article-title":"Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats","volume":"74","author":"Kajstura J.","year":"1996","journal-title":"Laboratory Investigation"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.03.021"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020394"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.20.3771"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010041"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2018.11.004"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03234-8"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000159"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2013.01.007"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1186"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000305"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03329-X"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6345-7"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.10.004"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111015"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S195412"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.908529"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.009280"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2011.07.006"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.04.004"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/1115749.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/1115749.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/1115749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:26:19Z","timestamp":1748913979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/1115749"}},"subtitle":[],"editor":[{"given":"Ding-Sheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/1115749"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1115749","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1115749"}}