{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:42:20Z","timestamp":1790847740518,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Qionghai People\u2019s Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,9,21]]},"abstract":"<jats:p>Objective. We aimed to explore the effect of blood lipid parameters on the risk of primary open-angle glaucoma (POAG) by meta-analysis. Methods. The databases of PubMed, Scopus, CNKI, and Wanfang were systematically searched from inception to April 2022, and the relevant research literature was obtained, screened, and analyzed. Results. A total of 15 studies were included in this meta-analysis, including 11 reporting dyslipidemia and risk of POAG and 5 reporting specific lipid level and risk of POAG. Dyslipidemia increased the risk of POAG with an odd ratio (OR) of 1.25 (95% CI: 1.23, 1.26). Total triglyceride and total cholesterol were not related to the prevalence of POAG, but high-density lipoprotein cholesterol was significantly negatively correlated with the risk of POAG with an OR of 0.96 (95% CI: 0.94, 0.99). Conclusion. Dyslipidemia is a risk factor for POAG. Given the small sample size and significant interstudy heterogeneity, additional studies are needed to establish this conclusion.<\/jats:p>","DOI":"10.1155\/2022\/1122994","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:20:08Z","timestamp":1663806008000},"page":"1-8","source":"Crossref","is-referenced-by-count":13,"title":["Meta-Analysis of Dyslipidemia and Blood Lipid Parameters on the Risk of Primary Open-Angle Glaucoma"],"prefix":"10.1155","volume":"2022","author":[{"given":"Guimei","family":"Huang","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Qionghai People's Hospital, Qionghai, 571400 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wang","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Qionghai Jianping Hospital, Qionghai, 571400 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, 570311 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, 570311 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-4930","authenticated-orcid":true,"given":"Yijie","family":"Yan","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, 570311 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.21899"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16257-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.1110"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.11.004"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31469-1"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72121-X"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08295-1"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym018"},{"key":"10","article-title":"AHRQ methods for effective health care assessing the risk of bias of individual studies in systematic reviews of health care interventions","volume-title":"Methods Guide for Effectiveness and Comparative Effectiveness Reviews. 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