{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:58:35Z","timestamp":1788393515785,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liaoning Province Science and Technology Project","award":["2021JH2\/10300085"],"award-info":[{"award-number":["2021JH2\/10300085"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,9,14]]},"abstract":"<jats:p>Objective. To analyze the effect of sperm DNA fragmentation index (DFI) on the outcomes of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Methods. Literature search was conducted on English databases PubMed, Cochrane, and Embase to obtain eligible studies. Results. A total of 11 cohort studies were included and analyzed using the random effects model. The results illustrated that the IVF fertilization rate (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>RR<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.94<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI: 0.77-1.14, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.61<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), pregnancy rate (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>RR<\/e:mtext>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.83<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, 95% CI: 0.57-1.21, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.32<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>), and live birth rate (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>RR<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.53<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, 95% CI: 0.16-1.80, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.31<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>) in the high DFI group were statistically insignificant with those in the low FI group. The correlations between DFI and ICSI fertilization rate (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>RR<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.79<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, 95% CI: 0.52-1.18, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.25<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>), pregnancy rate (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mtext>RR<\/q:mtext>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.89<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>, 95% CI: 0.74-1.06, <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>P<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.18<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>), and live birth rate (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mtext>RR<\/u:mtext>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.89<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>, 95% CI: 0.70-1.14, <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>P<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.36<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>) were also not statistically significant. Conclusion. This study has observed no significant correlation between sperm DFI and assisted reproductive outcomes. Multicenter large-sample clinical trials are required to conclusively determine the impact of DNA damage on the clinical outcomes of assisted reproduction.<\/jats:p>","DOI":"10.1155\/2022\/1126616","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T01:20:29Z","timestamp":1663204829000},"page":"1-8","source":"Crossref","is-referenced-by-count":20,"title":["The Association of Sperm DNA Fragment and Assisted Reproductive Outcomes: A Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yue","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medical Center, PLA North Military Command Region General Hospital, Shenyang 110000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4123-5741","authenticated-orcid":true,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory, General Hospital of the Northern Theater of the Chinese People's Liberation Army, Shenyang 110000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew123"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-07-0152"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/and.13615"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00995.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2011.553984"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del019"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12215"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del326"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh280"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179002"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01632-5"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S1642-431X(12)60095-3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.77"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq116"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2019.06.22"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei266"},{"issue":"12","key":"17","first-page":"1083","article-title":"Sperm chromatin integrity test for predicting the outcomes of IVF and ICSI","volume":"17","author":"H. 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