{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:31:19Z","timestamp":1783485079865,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":322,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental and Public Health"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Postoperative delirium (POD) is very common in the elderly surgical population, and its occurrence is associated with multiple factors such as preoperative, intraoperative, and postoperative factors, and the increase of serum inflammatory markers such as C\u2010reactive protein (CRP) and interleukin\u20106 (IL\u20106) is considered to be associated with the occurrence of POD, but the results of multiple studies are inconsistent. In this study, we investigated the correlation between inflammatory markers CRP and IL\u20106 and POD in elderly patients by literature search and meta\u2010analysis. <jats:italic>Methods<\/jats:italic>. We searched PubMed, Web of Science, the Cochrane library, Embase, Ovid, and Springer Link for cohort studies or case\u2010control studies that investigated the factors involved in the occurrence of POD, used the Newcastle\u2010Ottawa Scale (NOS) to assess the quality of the selected literature, and combined the differences in serum CRP and IL\u20106 levels between POD and non\u2010POD patients after surgery to evaluate the predictive value of CRP and IL\u20106 for the occurrence of POD. <jats:italic>Results<\/jats:italic>. This research comprised 16 papers for quantitative analysis, with a total of 2967 patients, 758 with POD and 2209 with non\u2010POD. There were 16 cohort studies (100%) and 0 case\u2010control studies (0%) across all the collected literatures; there were 15 prospective cohort studies and 1 retrospective cohort research. A meta\u2010analysis revealed a statistically significant difference in serum IL\u20106 levels between POD patients after surgery and non\u2010POD patients [MD = 115.68, 95% CI (25.70, 206.66), <jats:italic>Z<\/jats:italic> = 2.52, <jats:italic>P<\/jats:italic> = 0.012], as well as a statistically significant difference in serum CRP levels [MD = 27.67, 95% CI (12.77, 42.58), <jats:italic>Z<\/jats:italic> = 3.64, <jats:italic>P<\/jats:italic> = 0.0003]. <jats:italic>Discussion<\/jats:italic>. Early after surgery, serum IL\u20106 and CRP levels were considerably higher in POD patients than in non\u2010POD patients, indicating that early serum inflammatory variables are likely to be predictors of POD. After surgery, the levels of the aforementioned inflammatory factors should be actively monitored to forecast the emergence of delirium, and active treatment should be used to limit the creation and release of the aforementioned inflammatory factors.<\/jats:p>","DOI":"10.1155\/2022\/1136386","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T17:05:10Z","timestamp":1668877510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["[Retracted] Correlation Analysis of Inflammatory Markers CRP and IL\u20106 and Postoperative Delirium (POD) in Elderly Patients: A Meta\u2010Analysis of Observational Studies"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-069X","authenticated-orcid":false,"given":"Xiaoling","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0695-x"},{"key":"e_1_2_7_2_2","first-page":"448","article-title":"Postoperative delirium","volume":"77","author":"Whitlock E. 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