{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:23:51Z","timestamp":1782771831022,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Project of Guangxi Health Commission","award":["Z20190977"],"award-info":[{"award-number":["Z20190977"]}]},{"name":"Scientific Research Project of Guangxi Health Commission","award":["S2020012"],"award-info":[{"award-number":["S2020012"]}]},{"name":"Scientific Research Project of Guangxi Health Commission","award":["2018GXNSFBA050069"],"award-info":[{"award-number":["2018GXNSFBA050069"]}]},{"name":"Scientific Research Project of Guangxi Health Commission","award":["2017GXNSFBA198043"],"award-info":[{"award-number":["2017GXNSFBA198043"]}]},{"name":"Scientific Research Project of Guangxi Health Commission","award":["G202003010"],"award-info":[{"award-number":["G202003010"]}]},{"name":"Scientific Research Project of Guangxi Health Commission","award":["81660132"],"award-info":[{"award-number":["81660132"]}]},{"name":"Scientific Research Project of Guangxi Health Commission","award":["GuiKeAB22080088"],"award-info":[{"award-number":["GuiKeAB22080088"]}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["Z20190977"],"award-info":[{"award-number":["Z20190977"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["S2020012"],"award-info":[{"award-number":["S2020012"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2018GXNSFBA050069"],"award-info":[{"award-number":["2018GXNSFBA050069"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2017GXNSFBA198043"],"award-info":[{"award-number":["2017GXNSFBA198043"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["G202003010"],"award-info":[{"award-number":["G202003010"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["81660132"],"award-info":[{"award-number":["81660132"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["GuiKeAB22080088"],"award-info":[{"award-number":["GuiKeAB22080088"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-Level Medical Expert Training Program of Guangxi \u201c139\u201d Plan Funding","award":["Z20190977"],"award-info":[{"award-number":["Z20190977"]}]},{"name":"High-Level Medical Expert Training Program of Guangxi \u201c139\u201d Plan Funding","award":["S2020012"],"award-info":[{"award-number":["S2020012"]}]},{"name":"High-Level Medical Expert Training Program of Guangxi \u201c139\u201d Plan Funding","award":["2018GXNSFBA050069"],"award-info":[{"award-number":["2018GXNSFBA050069"]}]},{"name":"High-Level Medical Expert Training Program of Guangxi \u201c139\u201d Plan Funding","award":["2017GXNSFBA198043"],"award-info":[{"award-number":["2017GXNSFBA198043"]}]},{"name":"High-Level Medical Expert Training Program of Guangxi \u201c139\u201d Plan Funding","award":["G202003010"],"award-info":[{"award-number":["G202003010"]}]},{"name":"High-Level Medical Expert Training Program of Guangxi \u201c139\u201d Plan Funding","award":["81660132"],"award-info":[{"award-number":["81660132"]}]},{"name":"High-Level Medical Expert Training Program of Guangxi \u201c139\u201d Plan Funding","award":["GuiKeAB22080088"],"award-info":[{"award-number":["GuiKeAB22080088"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Z20190977"],"award-info":[{"award-number":["Z20190977"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["S2020012"],"award-info":[{"award-number":["S2020012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018GXNSFBA050069"],"award-info":[{"award-number":["2018GXNSFBA050069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017GXNSFBA198043"],"award-info":[{"award-number":["2017GXNSFBA198043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["G202003010"],"award-info":[{"award-number":["G202003010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660132"],"award-info":[{"award-number":["81660132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GuiKeAB22080088"],"award-info":[{"award-number":["GuiKeAB22080088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research & Development Program of Guangxi","award":["Z20190977"],"award-info":[{"award-number":["Z20190977"]}]},{"name":"Key Research & Development Program of Guangxi","award":["S2020012"],"award-info":[{"award-number":["S2020012"]}]},{"name":"Key Research & Development Program of Guangxi","award":["2018GXNSFBA050069"],"award-info":[{"award-number":["2018GXNSFBA050069"]}]},{"name":"Key Research & Development Program of Guangxi","award":["2017GXNSFBA198043"],"award-info":[{"award-number":["2017GXNSFBA198043"]}]},{"name":"Key Research & Development Program of Guangxi","award":["G202003010"],"award-info":[{"award-number":["G202003010"]}]},{"name":"Key Research & Development Program of Guangxi","award":["81660132"],"award-info":[{"award-number":["81660132"]}]},{"name":"Key Research & Development Program of Guangxi","award":["GuiKeAB22080088"],"award-info":[{"award-number":["GuiKeAB22080088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2022,10,10]]},"abstract":"<jats:p>Regulatory T cells (Tregs) and M2c macrophages have been shown to exert potentially synergistic therapeutic effects in animals with adriamycin-induced nephropathy (AN), a model chronic proteinuric renal disease. M2c macrophages may protect against renal injury by promoting an increase in the number of Tregs in the renal draining lymph nodes of AN mice, but how they do so is unclear. In this study, we used an AN mouse model to analyze how M2c macrophages induce the migration of Tregs. Using flow cytometry, we found that M2c macrophages promoted the migration of Tregs from the peripheral blood to the spleen, thymus, kidney, and renal draining lymph nodes. At the same time, M2c macrophages significantly upregulated chemokine receptors and adhesion molecule in Tregs, including CCR4, CCR5, CCR7, CXCR5, and CD62L. Treating AN mice with monoclonal anti-CD62L antibody inhibited the migration of M2c macrophages and Tregs to the spleen, thymus, kidney, and renal draining lymph nodes. Taken together, our results suggest that M2c macrophages upregulate CD62L in Tregs and thereby promote their migration to inflammatory sites, where they exert renoprotective effects. These insights may aid the development of treatments against chronic kidney disease.<\/jats:p>","DOI":"10.1155\/2022\/1153300","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T01:20:51Z","timestamp":1665451251000},"page":"1-11","source":"Crossref","is-referenced-by-count":8,"title":["M2c Macrophages Protect Mice from Adriamycin-Induced Nephropathy by Upregulating CD62L in Tregs"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7967-0813","authenticated-orcid":true,"given":"Junyu","family":"Lu","sequence":"first","affiliation":[{"name":"Intensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqiu","family":"Lv","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielong","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Qin","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yegui","family":"Yang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-899X","authenticated-orcid":true,"given":"Geng","family":"Yang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-9310","authenticated-orcid":true,"given":"Jianfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8871-2_1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60687-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61601-9"},{"issue":"12","key":"4","first-page":"776","article-title":"Chronic kidney disease: detection and evaluation","volume":"96","author":"D. Y. Gaitonde","year":"2017","journal-title":"American Family Physician"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.66.S1.3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014090927"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.412"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13140"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12445"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011090914"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.259"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.717903"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00883"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500801"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.021"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/nri3605"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/nri3514"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030229"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.01.002"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03534-7"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02716"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00304"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012010070"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00621"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2017.11.001"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.2741\/2692"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002275"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.135"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.14800\/macrophage.679"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034219"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010030269"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00236.2017"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1004"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.341"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0110-2"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37218-x"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005080842"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005090978"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80165-x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.008"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.12.022"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203205"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2004.04.007"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1395.014"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1038\/nri2297"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009020133"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131142"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242614"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0757-4_5"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/645643"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1159\/000154854"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6143.2003.00293.x"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-2044"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01068"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.09.004"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/1153300.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/1153300.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2022\/1153300.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T01:21:04Z","timestamp":1665451264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2022\/1153300\/"}},"subtitle":[],"editor":[{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,10]]},"references-count":57,"alternative-id":["1153300","1153300"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1153300","relation":{},"ISSN":["1466-1861","0962-9351"],"issn-type":[{"value":"1466-1861","type":"electronic"},{"value":"0962-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,10]]}}}