{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:04:10Z","timestamp":1782471850943,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":156,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>In clinical practice, osteoarthritis (OA) is frequently misdiagnosed as rheumatoid arthritis (RA) and osteonecrosis (ON), leading to wrong treatment and disease progression. Circular RNA\u2010 (circRNA\u2010) 016901 affects the recovery of irradiation\u2010induced injury in the bone, while its role in OA is unclear. This study is aimed at exploring the role of circRNA\u2010016901 in improving the diagnostic accuracy of OA. The present study included patients with OA (<jats:italic>n<\/jats:italic> = 80), patients with RA (<jats:italic>n<\/jats:italic> = 80), patients with ON (<jats:italic>n<\/jats:italic> = 80), and healthy controls (HCs, <jats:italic>n<\/jats:italic> = 80) to collect plasma samples before and after treatment. RT\u2010qPCR was performed to detect RNA accumulation of circRNA\u2010016901 in plasma samples from all participants. The role of plasma expression of circRNA\u2010016901 in predicting OA was studied with ROC curve analysis. Association between plasma expression of circRNA\u2010016901 and patients\u2019 clinical features was analyzed with the chi\u2010squared test. Compared to HCs, increased accumulation of circRNA\u2010016901 was only observed in the OA group, but not in the RA and ON groups before treatment. OA patients were effectively separated from the RA, ON, and HC groups using plasma expression of circRNA\u2010016901 before treatment as a biomarker. Plasma expression of circRNA\u2010016901 was closely associated with OA patients\u2019 disease severity. After treatment, decreased plasma expression levels of circRNA\u2010016901 were only observed in OA patients, while no alteration in plasma circRNA\u2010016901 accumulation was observed in the RA and ON groups. In conclusion, circRNA\u2010016901 is accumulated to high levels in OA and may be applied to improve the diagnostic accuracy of OA.<\/jats:p>","DOI":"10.1155\/2022\/1158562","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:21:12Z","timestamp":1654579272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Application of circRNA\u2010016901 in Improving the Diagnostic Accuracy of Osteoarthritis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9592-629X","authenticated-orcid":false,"given":"Mingchang","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8213-0794","authenticated-orcid":false,"given":"Ye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000479"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40928"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203355"},{"key":"e_1_2_10_5_2","first-page":"49","article-title":"Osteoarthritis: diagnosis and treatment","volume":"85","author":"Sinusas K.","year":"2012","journal-title":"American Family Physician"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.4172\/1758-4272.1000152"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3845"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.248"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-eular.5150"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2013.11.010"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180542"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566523219666190716092203"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2019.29050.gde"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9786"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13103"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2019.12.004"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9070785"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000491469"},{"key":"e_1_2_10_21_2","unstructured":"ChineseP. 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Analysis of differentially expressed genes in osteonecrosis of femoral head osteoarthritis and rheumatoid arthritis by integrated microarray analysis 2021."},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23858"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2019.0036"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/1158562.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/1158562.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/1158562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T20:31:15Z","timestamp":1735677075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/1158562"}},"subtitle":[],"editor":[{"given":"Nabil","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/1158562"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1158562","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1158562"}}