{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:45:53Z","timestamp":1787237153803,"version":"build-2736575974"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","award":["KAUMS\/98163"],"award-info":[{"award-number":["KAUMS\/98163"]}],"id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    . Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and serum lipid content in patients receiving MMTPs.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . A randomized, double\u2010blind, placebo\u2010controlled trial was conducted among 70 patients receiving MMTPs to receive either 1.8\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \u2009CFU\/day probiotics (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200935) or placebo (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200935) for 12 weeks. Clinical symptoms and metabolic profiles were measured before and after the intervention in patients receiving MMTPs.\n                    <jats:italic>Results<\/jats:italic>\n                    . Compared with the placebo group, probiotic supplementation resulted in a significant improvement in the severity of depression (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). In addition, probiotic administration significantly decreased fasting plasma glucose (FPG), total cholesterol, and low\u2010density lipoprotein cholesterol (LDL cholesterol) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Furthermore, probiotics resulted in a significant reduction in high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) and a significant elevation in total antioxidant capacity (TAC) and total glutathione (GSH) levels (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Treatment with probiotics for 12 weeks to patients receiving MMTPs had beneficial effects on symptoms of depression, as well as several metabolic profiles. Clinical Trial Registration: this study was registered in the Iranian website (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.irct.ir\">https:\/\/www.irct.ir<\/jats:ext-link>\n                    ) for clinical trials registration (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/fa.irct.ir\/trial\/46363\/IRCT20170420033551N9\">https:\/\/fa.irct.ir\/trial\/46363\/IRCT20170420033551N9<\/jats:ext-link>\n                    ). The registration date is March 22, 2020.\n                  <\/jats:p>","DOI":"10.1155\/2022\/1206914","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:05:34Z","timestamp":1648645534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Effects of Probiotic Supplementation on Opioid\u2010Related Disorder in Patients under Methadone Maintenance Treatment Programs"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-7626","authenticated-orcid":false,"given":"Nader","family":"Molavi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-5833","authenticated-orcid":false,"given":"Morad","family":"Rasouli-Azad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-8281","authenticated-orcid":false,"given":"Hamed","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9106-0249","authenticated-orcid":false,"given":"Amir Hassan","family":"Matini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-8861","authenticated-orcid":false,"given":"Hamid Reza","family":"Banafshe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-3630","authenticated-orcid":false,"given":"Marjan","family":"Valiollahzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-789X","authenticated-orcid":false,"given":"Majid","family":"Hassanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2389-4070","authenticated-orcid":false,"given":"Ahmad Reza","family":"Saghazade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-6319","authenticated-orcid":false,"given":"Samira","family":"Abbaszadeh-Mashkani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2333-7389","authenticated-orcid":false,"given":"Peyman","family":"Mamsharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-6039","authenticated-orcid":false,"given":"Amir","family":"Ghaderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"e_1_2_13_1_2","unstructured":"Drugs UNOo Crime World drug report 2019: 35 million people worldwide suffer from drug use disorders while only 1 in 7 people receive treatment 2019 https:\/\/www.unodc.org\/unodc\/en\/frontpage\/2019\/June\/world-drug-report-2019_-35-million-people-worldwide-suffer-from-drug-use-disorders-while-only-1-in-7-people-receive-treatment.html."},{"key":"e_1_2_13_2_2","doi-asserted-by":"crossref","DOI":"10.4103\/jehp.jehp_984_20","article-title":"Factors affecting substance use relapse among Iranian addicts","volume":"10","author":"Mousali A. 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