{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:15:51Z","timestamp":1769231751157,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":157,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Rhinocerebral mucormycosis is a serious invasive fungal infection that is one of the most aggressive and lethal of invasive mycoses. The coronavirus disease (COVID\u201019) has been linked to immune dysregulation, and patients with COVID\u201019 have been reported to be at risk for developing invasive fungal infections. This study is conducted to evaluate the concurrence of mucormycosis among COVID\u201019 patients. <jats:italic>Methods<\/jats:italic>. In this retrospective, cross\u2010sectional study, hospital records of patients with mucormycosis, as well as COVID\u201019 admitted to Khalili Hospital, as the major referral center for functional endoscopic sinus surgery (FESS) in southern Iran, were collected. Demographic and clinical information was extracted and subsequently analyzed. <jats:italic>Results<\/jats:italic>. Among 59 mucormycosis patients undergoing FESS, 41 (69.5%) were during the COVID\u201019 pandemic, while 18 (30.5%) were during one year before the COVID\u201019 pandemic. The average age was 49.33\u2009\u00b1\u200920.52, and 64.4% had diabetes mellitus, while 62.7% had COVID\u201019. The most common presentation was periorbital edema (56.9%), followed by necrotic tissue (48.3%). Although the total number of cases increased during the COVID\u201019 period compared to the case before the pandemic, the overall pattern and features of the patients had no significant difference, except regarding a significant increase in the presentation of necrotic tissue and also the use of corticosteroids. Most cases developed mucormycosis two weeks after COVID\u201019. The overall mortality was 36.8%, which is not statistically associated with COVID\u201019. <jats:italic>Conclusion<\/jats:italic>. Even in the absence of comorbidities, physicians should be aware of the risk of secondary fungal infections in patients with COVID\u201019 who were treated with corticosteroids.<\/jats:p>","DOI":"10.1155\/2022\/1248325","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T19:20:17Z","timestamp":1654629617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation and Comparison of Mucormycosis Patients\u2019 Features Undergoing Functional Endoscopic Sinus Surgery Prior to and during the COVID\u201019 Pandemic: A Case\u2010Control 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