{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:52:20Z","timestamp":1767167540633,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Medical and Health Plan Project","award":["2020KY1026"],"award-info":[{"award-number":["2020KY1026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2022,1,17]]},"abstract":"<jats:p>Quetiapine combined with sodium valproate is an effective and more suitable drug treatment for Alzheimer\u2019s disease. At present, there are relatively few studies on the combined action mechanism of these two drugs. This study has certain practical value. Alzheimer\u2019s disease is a multifaceted, highly genetically heterogeneous neurodegenerative disease. The main clinical manifestations are memory loss, abnormal mental behavior, and loss of various cognitive functions. In order to improve the symptoms of patients with Alzheimer\u2019s disease, especially those with mental symptoms, this article combines quetiapine and sodium valproate, two commonly used drugs for the treatment of mental illnesses, and applies them to different levels of Alzheimer\u2019s and observes the results of the combination\u2019s curative effect. This article introduces Alzheimer\u2019s disease and its potential mental behaviors in the method section, and it also introduces the mechanism of action of quetiapine and sodium valproate. For the algorithm, this paper introduces a data mining algorithm to understand the effect of drug efficacy. In the experimental part, firstly, it introduces the experimental objects, the proportion of medicines, and the statistical methods. Secondly, this article covers adverse reactions, inflammatory factors and vascular endothelial indicators, Alzheimer\u2019s disease performance, MOAS score, treatment effect evaluation, and satisfaction surveys. It can be seen from the experiment that, in mental behavior, the experimental group decreased from 8.2 before treatment to 0.5, and the control group decreased from 7.1 before treatment to 2.6. It can be seen that the scores of the experimental group changed after receiving the treatment of quetiapine combined with sodium valproate.<\/jats:p>","DOI":"10.1155\/2022\/1278092","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T13:50:22Z","timestamp":1642427422000},"page":"1-12","source":"Crossref","is-referenced-by-count":2,"title":["Quetiapine Combined with Sodium Valproate in Patients with Alzheimer\u2019s Disease with Mental and Behavioral Symptoms Efficacy Observation"],"prefix":"10.1155","volume":"2022","author":[{"given":"Zhihua","family":"Zhang","sequence":"first","affiliation":[{"name":"Senile Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiating","family":"Xu","sequence":"additional","affiliation":[{"name":"Senile Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penghao","family":"Xu","sequence":"additional","affiliation":[{"name":"Senile Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Senile Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyan","family":"He","sequence":"additional","affiliation":[{"name":"Senile Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-5776","authenticated-orcid":true,"given":"Kedeng","family":"Fu","sequence":"additional","affiliation":[{"name":"Senile Psychiatry Department, The Third Hospital of Quzhou, Quzhou 324000, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"3","key":"1","first-page":"280","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease","volume":"7","author":"R. A. Sperling","year":"2016","journal-title":"Alzheimer\u2019s and Dementia"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1037\/a0017369","article-title":"Emotion perception in Alzheimer\u2019s disease and mood disorder in old age","volume":"25","author":"L. H. Phillips","year":"2016","journal-title":"Psychology and Aging"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.future.2020.03.039"},{"issue":"1-2","key":"4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1155\/2009\/836437","article-title":"Applications of neuroimaging to disease-modification trials in Alzheimer\u2019s disease","volume":"21","author":"A. S. Fleisher","year":"2016","journal-title":"Behavioural Neurology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.5.408"},{"issue":"11","key":"6","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.19082\/3257","article-title":"Relationship between bone density and biochemical markers of bone among two groups taking carbamazepine and sodium valproate for epilepsy in comparison with healthy individuals in yazd","volume":"8","author":"R. Abolghasem","year":"2016","journal-title":"Electronic Physician"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1109\/jbhi.2019.2891526"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2019.6.n536"},{"issue":"6","key":"9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.5114\/ada.2017.72462","article-title":"Twenty years\u2019 observation of subcutaneous pollen allergoid immunotherapy efficacy in adults","volume":"34","author":"B. Andrzej","year":"2017","journal-title":"Advances in Dermatology & Allergology\/postpy Dermatologii I Alergologii"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2016.07.001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.comnet.2019.04.016"},{"issue":"6","key":"12","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/01926230490520232","article-title":"Brain inflammation and alzheimer\u2019s-like pathology in individuals exposed to severe air pollution","volume":"32","author":"L. Calder\u00f3n-Garcidue\u00f1as","year":"2016","journal-title":"Toxicologic Pathology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/s13640-018-0367-6"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/WAD.0b013e31815958eb","article-title":"Alzheimer disease and associated disorders","volume":"21","author":"C. DeCarli","year":"2018","journal-title":"Alzhmer Disease & Associated Disorders"},{"issue":"5","key":"16","first-page":"430","article-title":"Effects of lycopene and sodium valproate on pentylenetetrazol-induced kindling in mice","volume":"41","author":"V. Kumar","year":"2016","journal-title":"Iranian Journal of Medical Sciences"},{"issue":"5","key":"17","first-page":"42","article-title":"The experiential comparison of levetiracetam efficacy in migraine headache with sodium valproate","volume":"2","author":"H. Mehran","year":"2016","journal-title":"The Italian Journal of Neurological Sciences"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1159\/000447087"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jced.9b01069"},{"issue":"6","key":"20","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.3892\/etm.2017.4324","article-title":"Sex-related differences of urethane and sodium valproate effects on Ki-67 expression in urethane-induced lung tumors of mice","volume":"13","author":"S. Donatas","year":"2017","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"112","key":"21","first-page":"S254","article-title":"PO18-WE-39 the investigation of insulin resistance in two groups of epileptic patients treated with sodium valproate and carbamazepine","volume":"285","author":"M. R. Najafi","year":"2017","journal-title":"Journal of the Neurological Sciences"},{"issue":"7284","key":"22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/bmj.322.7284.443","article-title":"Physical health of people with severe mental illness","volume":"322","author":"M. Phelan","year":"2016","journal-title":"BMJ Clinical Research"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1109\/JIOT.2014.2329462"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1177\/1049731505282593"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/s2215-0366(15)00505-2"}],"updated-by":[{"DOI":"10.1155\/2023\/9860560","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"record-id":"56250"},{"DOI":"10.1155\/2023\/9860560","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000}}],"container-title":["Journal of Healthcare Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/1278092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/1278092.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/1278092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T13:50:38Z","timestamp":1642427438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jhe\/2022\/1278092\/"}},"subtitle":[],"editor":[{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":25,"alternative-id":["1278092","1278092"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1278092","relation":{},"ISSN":["2040-2309","2040-2295"],"issn-type":[{"value":"2040-2309","type":"electronic"},{"value":"2040-2295","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,17]]}}}