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In recent years, there has been a rapid development in mitochondria\u2010targeting pharmacological strategies as mitochondrial biogenesis, morphology, and function, as well as dynamic changes in mitochondria, have been studied in disease states. Mitochondria\u2010targeting drugs include nicotinamide mononucleotide, which supplements the NAD+ pool; mitochondria\u2010targeted protective compounds, such as MitoQ; the antioxidant coenzyme, Q10; and cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. However, traditional drugs targeting mitochondria have limited clinical applications due to their inability to be effectively absorbed by mitochondria <jats:italic>in vivo<\/jats:italic> and their high toxicity. Recently, SS\u201031, a mitochondria\u2010targeting antioxidant, has received significant research attention as it decreases mitochondrial reactive oxygen species production and prevents mitochondrial depolarization, mitochondrial permeability transition pore formation, and Ca<jats:sup>2+<\/jats:sup>\u2010induced mitochondrial swelling, and has no effects on normal mitochondria. At present, few studies have evaluated the effects of SS\u201031 against renal diseases, and the mechanism underlying its action is unclear. In this review, we first discuss the pharmacokinetics of SS\u201031 and the possible mechanisms underlying its protective effects against renal diseases. Then, we analyze its renal disease\u2010improving effects in various experimental models, including animal and cell models, and summarize the clinical evidence of its benefits in renal disease treatment. Finally, the potential mechanism underlying the action of SS\u201031 against renal diseases is explored to lay a foundation for future preclinical studies and for the evaluation of its clinical applications.<\/jats:p>","DOI":"10.1155\/2022\/1295509","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:35:43Z","timestamp":1654580143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["SS\u201031, a Mitochondria\u2010Targeting Peptide, Ameliorates Kidney 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