{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:42:16Z","timestamp":1790707336069,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":123,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21Y11903500"],"award-info":[{"award-number":["21Y11903500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16411953300"],"award-info":[{"award-number":["16411953300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["201701018"],"award-info":[{"award-number":["201701018"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Trigeminal neuralgia (TN) is a chronic neuropathic pain disorder characterized by spontaneous and elicited paroxysms of electric\u2010shock\u2010like or stabbing pain in a region of the face. The epigenetic regulation of TN is still obscure. In current study, a rat TN model subject to carbamazepine (CBZ) treatment was established, and transcriptome\u2010 and genome\u2010scale profiling of H3K9ac and HDAC3 was performed by RNA\u2010seq and ChIP\u2010seq. We observed that H3K9ac levels in the trigeminal ganglion were lower in the TN rats compared with those in the control, and CBZ treatment led to recovery of H3K9ac levels. Further, we found that HDAC3 was overactivated, which interfered with H3K9 acetylation due to higher phosphorylation in TN compared with that in the control. Finally, the phosphokinase leucine\u2010rich repeat kinase 2 (LRRK2) was demonstrated to contribute to HDAC3 activity via the MAPK signaling pathway. Taken together, we identified a regulatory mechanism in which the phosphate groups transferred from activated ERK and LRRK2 to HDAC3 caused genome\u2010scale deacetylation at H3K9 and resulted in the silencing of a large number of genes in TN. The kinases or important enzymes within this regulatory axis may represent important targets for TN therapy and prevention.<\/jats:p>","DOI":"10.1155\/2022\/1300387","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:50:12Z","timestamp":1651711812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of Acetylation of Histone H3 at Lysine 9 in the Trigeminal Ganglion of a Rat Trigeminal Neuralgia Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5930-5963","authenticated-orcid":false,"given":"Wenbin","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8733-3198","authenticated-orcid":false,"given":"Yuemin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-6953","authenticated-orcid":false,"given":"Yating","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-4430","authenticated-orcid":false,"given":"Minjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-5132","authenticated-orcid":false,"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-8184","authenticated-orcid":false,"given":"Zixiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-5523","authenticated-orcid":false,"given":"Ying","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416687280"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000223501.27220.69"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0356-0"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13243"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.5.JNS172948"},{"key":"e_1_2_9_6_2","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918796763","article-title":"Histone deacetylase inhibitors prevent persistent hypersensitivity in an orofacial neuropathic pain model","volume":"14","author":"Danaher R. J.","year":"2018","journal-title":"Molecular Pain"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.021"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1259-19.2020"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.03.033"},{"key":"e_1_2_9_10_2","doi-asserted-by":"crossref","DOI":"10.1177\/1744806920901890","article-title":"Trigeminal neuralgia: an overview from pathophysiology to pharmacological treatments","volume":"16","author":"Gambeta E.","year":"2020","journal-title":"Molecular Pain"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.37230"},{"key":"e_1_2_9_12_2","first-page":"187","article-title":"An animal model for trigeminal neuralgia by compression of the trigeminal nerve root","volume":"15","author":"Luo D. S.","year":"2012","journal-title":"Pain Physician"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2017.09.002"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13204"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_9_16_2","unstructured":"AndrewsS.andFastQCA. Quality Control Tool for High Throughput Sequence Data 2013."},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3172"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.626536"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.05.014"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.07.006"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010078"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12539-019-00354-7"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00376"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3767"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25914"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.643874"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw363"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27378"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.4097\/kja.d.18.00022"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13050357"},{"key":"e_1_2_9_36_2","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918798408","article-title":"The etiological changes of acetylation in peripheral nerve injury-induced neuropathic hypersensitivity","volume":"14","author":"Wang X.","year":"2018","journal-title":"Molecular Pain"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.02.034"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13788"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00219"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005879"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03599-4"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/1300387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/1300387.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/1300387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:48:02Z","timestamp":1748915282000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/1300387"}},"subtitle":[],"editor":[{"given":"Ajinkya","family":"Sase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/1300387"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1300387","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1300387"}}