{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:13:17Z","timestamp":1772309597703,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002471","name":"Dongguk University","doi-asserted-by":"publisher","award":["NRF-2019R1F1A1059856"],"award-info":[{"award-number":["NRF-2019R1F1A1059856"]}],"id":[{"id":"10.13039\/501100002471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2019R1F1A1059856"],"award-info":[{"award-number":["NRF-2019R1F1A1059856"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,3,23]]},"abstract":"<jats:p>Atopic dermatitis (AD) is a common inflammatory skin disease, which can be worsened under sleep deprivation (SD) conditions. This study investigated the efficacy and the mechanism of action of the traditional herbal formula Seungmagalgeun-tang (SMGGT) on the inflammation and behavioral changes in a mouse model of AD exposed to SD. SMGGT decreased levels of IgE, TNF-\u03b1, IL-4, IL-13, and mast cell infiltration and reduced the expression of CD3 in the mouse skin. SMGGT also reversed the SD-induced increase in corticosterone and decrease in melatonin level. Furthermore, SMGGT reduced the immobility time in the tail suspension test significantly. HaCaT cells and HMC-1 cells were used to investigate the effects of SMGGT on cell signaling pathways. In TNF-\u03b1\/IFN-\u03b3 (TI) treated HaCaT cells, SMGGT reduced production of TARC\/CCL17 and MDC\/CCL22 and suppressed the p38 MAPK, STAT1, and NF-\u03baB pathways. In substance P (SP)\/CRH-stimulated HMC-1 cells, SMGGT decreased VEGF production and inhibited ERK phosphorylation. Network pharmacology and molecular docking analysis revealed that puerarin and paeoniflorin might contribute to the effects of SMGGT by targeting several AD-related molecules and pathways. Puerarin and paeoniflorin exerted anti-inflammatory effects by decreasing production of MDC\/CCL22 and IL-6 in TI-treated HaCaT cells and VEGF production in SP\/CRH-stimulated HMC-1 cells. This study suggests that SMGGT with puerarin and paeoniflorin as main bioactive components alleviates skin inflammation and depression-like behavior in a sleep-deprived mouse model of AD.<\/jats:p>","DOI":"10.1155\/2022\/1307173","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:50:09Z","timestamp":1648079409000},"page":"1-15","source":"Crossref","is-referenced-by-count":3,"title":["Seungmagalgeun-Tang, a Traditional Herbal Formula, Alleviates Skin Inflammation and Depression-Like Behavior in Atopic Dermatitis Mice under Sleep Deprivation Conditions"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0567-2562","authenticated-orcid":true,"given":"Ly","family":"Thi Huong Nguyen","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 38066, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4621-6352","authenticated-orcid":true,"given":"Min-Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 38066, Republic of Korea"},{"name":"R&D Center, Etnova Therapeutics Corp., 124, Sagimakgol-ro, Jungwon-gu, Gyeonggi-do 13207, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1226-3206","authenticated-orcid":true,"given":"Heung-Mook","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 38066, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-1325","authenticated-orcid":true,"given":"In-Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 38066, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.005"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.10.010"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.3092"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.08.014"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040462"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0376"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1037\/a0034219"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1159\/000107421"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-008-0050-6"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1188"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1159\/000069516"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00422"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.6116\/kjh.2013.28.5.7"},{"issue":"6","key":"14","first-page":"1572","article-title":"Anti-allergic effect of seungmagalgeun-tang through suppression of NF-\u03baB and p38 mitogen-activated protein kinase activation in the RBL-2H3 cells","volume":"22","author":"J. 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