{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:17Z","timestamp":1787017697741,"version":"build-2736575974"},"reference-count":6,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2022,4,6]]},"abstract":"<jats:p>Calcium regulation is tightly controlled in the body. Multiple causes of hypercalcemia have been studied including primary hyperparathyroidism, hypercalcemia of malignancy, and chronic granulomatous disorders. Among the less studied causes is calcium-alkali syndrome. Here, we discuss a case of hypercalcemia secondary to calcium-alkali syndrome, presenting with hypercalcemia, metabolic alkalosis, and acute kidney injury as a result of ingestion of a large amount of calcium supplements. Hypercalcemia can result in impaired collecting duct system sensitivity to antidiuretic hormone, afferent arteriole constriction, and activation of calcium sensor receptors in multiple tissues. The net effect is an increase in calcium reabsorption with a salt and water diuresis which leads to volume depletion, acute kidney injury, and metabolic alkalosis.<\/jats:p>","DOI":"10.1155\/2022\/1320259","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T19:20:09Z","timestamp":1649272809000},"page":"1-4","source":"Crossref","is-referenced-by-count":4,"title":["Hypercalcemia, Acute Kidney Injury, and Metabolic Alkalosis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-0926","authenticated-orcid":true,"given":"Faten","family":"Aqeel","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine, Department of Medicine, Division of Nephrology, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Del Castillo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, MedStar Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-7115","authenticated-orcid":true,"given":"Bernard G.","family":"Jaar","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Department of Medicine, Division of Nephrology, Baltimore, MD, USA"},{"name":"Nephrology Center of Maryland, Baltimore, MD, USA"},{"name":"The Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, MD, USA"},{"name":"The Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Hanouneh","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Department of Medicine, Division of Nephrology, Baltimore, MD, USA"},{"name":"Nephrology Center of Maryland, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab504"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4328-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010030255"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199503000-00004"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01451005"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00608.2009"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2022\/1320259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2022\/1320259.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2022\/1320259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T19:20:11Z","timestamp":1649272811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crin\/2022\/1320259\/"}},"subtitle":[],"editor":[{"given":"David","family":"Mudge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":6,"alternative-id":["1320259","1320259"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1320259","relation":{},"ISSN":["2090-665X","2090-6641"],"issn-type":[{"value":"2090-665X","type":"electronic"},{"value":"2090-6641","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,6]]}}}