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Sepsis can cause acute and long\u2010term brain dysfunction, namely, sepsis\u2010associated encephalopathy (SAE) and cognitive impairment. SAE refers to changes in consciousness without direct evidence of central nervous system infection. It is highly prevalent and may cause poor outcomes in sepsis patients. Cognitive impairment seriously affects the life quality of sepsis patients and increases the medical burden. The pathogenesis of sepsis\u2010induced brain dysfunction is mainly characterized by the interaction of systemic inflammation, blood\u2010brain barrier (BBB) dysfunction, neuroinflammation, microcirculation dysfunction, and brain dysfunction. Currently, the diagnosis of sepsis\u2010induced brain dysfunction is based on clinical manifestation of altered consciousness along with neuropathological examination, and the treatment is mainly involves controlling sepsis. Although treatments for sepsis\u2010induced brain dysfunction have been tested in animals, clinical treat sepsis\u2010induced brain dysfunction is still difficult. Therefore, we review the underlying mechanisms of sepsis\u2010induced brain injury, which mainly focus on the influence of systemic inflammation on BBB, neuroinflammation, brain microcirculation, and the brain function, which want to bring new mechanism\u2010based directions for future basic and clinical research aimed at preventing or ameliorating brain dysfunction.<\/jats:p>","DOI":"10.1155\/2022\/1328729","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T19:05:30Z","timestamp":1661367930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["Sepsis\u2010Induced Brain Dysfunction: Pathogenesis, Diagnosis, and 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