{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:56:23Z","timestamp":1777593383179,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":326,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974360"],"award-info":[{"award-number":["81974360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. High tibial osteotomy (HTO) is an effective surgery in treating medial compartment knee osteoarthritis (KOA) combined with varus deformity. An accurate orthopaedy is the key and challenge to the success of HTO. Therefore, we designed a calibratable patient\u2010specific instrumentation (PSI) to assist surgery and evaluated its accuracy and clinical outcomes by comparing with conventional operation (CO). <jats:italic>Materials and Methods<\/jats:italic>. 37 patients (39 knees) with medial compartment KOA were randomly divided into the PSI and CO groups and underwent medial open\u2010wedge high tibial osteotomy (MOWHTO) from September 2020 to May 2021. The postoperative radiological outcomes were compared with the preoperative measurements or target values to evaluate the accuracy of correction in the two groups. The American Knee Society Score (AKSS), complication rate, number of intraoperative radiation exposures, blood loss volume, and operative duration were analysed to evaluate the clinical outcomes in the two groups. <jats:italic>Results<\/jats:italic>. The designed target values were better achieved in the PSI group than in the CO group. The mean absolute difference between the postoperative measurements and preoperative targets was significantly lower in the PSI group than in the CO group (weight\u2010bearing line (WBL) ratio, 1.97 \u00b1 1.83<jats:italic>%<\/jats:italic> vs.5.42 \u00b1 4.41<jats:italic>%<\/jats:italic>, <jats:italic>P<\/jats:italic> = 0.002; hip\u2010knee\u2010ankle (HKA) angle, 1.12 \u00b1 0.86\u00b0 vs. 2.27 \u00b1 1.97\u00b0, <jats:italic>P<\/jats:italic> = 0.018). The operative duration was significantly shorter (<jats:italic>P<\/jats:italic> = 0.014), and the number of radiation exposures (<jats:italic>P<\/jats:italic> &lt; 0.001) and volume of intraoperative blood loss (<jats:italic>P<\/jats:italic> = 0.003) were significantly lower in the PSI group than in the CO group. The clinical AKSS score at 3 and 6 months postoperatively and the functional AKSS score at 3 months postoperatively were significantly higher in the PSI group than in the CO group (<jats:italic>P<\/jats:italic> = 0.042, 0.040, and 0.034, respectively). <jats:italic>Conclusion<\/jats:italic>. For patients with medial compartment KOA, calibratable PSI can assist the surgeon in MOWHTO with superior accuracy and clinical efficacy. This study was conducted under Randomized Controlled Trial Details (RCT) with Registry Number <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/showproj.aspx?proj=62100\">ChiCTR2000038619<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2022\/1378042","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T21:36:48Z","timestamp":1669325808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of Clinical and Radiological Outcomes between Calibratable Patient\u2010Specific Instrumentation and Conventional Operation for Medial Open\u2010Wedge High Tibial Osteotomy: A Randomized Controlled 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