{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:54:21Z","timestamp":1760954061635,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":242,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>The objective of this study was to investigate the value of PET\/CT imaging based on CNN image registration algorithm in evaluating the short\u2010term efficacy of PD\u20101 monoclonal antibody immunotherapy for lymphoma. 36 patients with advanced lymphoma confirmed by histology or cytochemistry and treated with PD\u20101 monoclonal antibody admitted to hospital were included. In addition, 38 normal controls were from healthy volunteers. All patients were treated with PD\u20101 monoclonal antibody intravenous infusion, and the image data were processed by CT with intelligent segmentation algorithm. Medication method: nivolumab 3\u2009mg\/kg for 2 weeks; pembrolizumab 2\u2009mg\/kg for 3 weeks; and continuous medication until tumor progression or unacceptable adverse reactions. Efficacy was evaluated every 3 cycles. Imaging examinations were performed after 3 weeks of medication to evaluate the therapeutic effect. The concentrations of IL\u20102, IL\u20107, basic fibroblast growth factor (FGF), granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF), platelet\u2010derived growth factor (PDGF\u2010bb), and other factors in the normal control group were significantly higher than those in the advanced lymphoma patients, and the differences were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.05). The PET\/CT imaging automatic segmentation accuracy of the CNN image registration algorithm was greater than 81%, and 27 patients were treated for more than 3 cycles, including 1 case of partial remission (PR) (3.7%), 16 cases of stable disease (SD) (59.3%) after 3 cycles of treatment, and 10 cases of progressive disease (PD) (37%). After 6 cycles of treatment, 1 case was PR (8.3%), 7 cases were SD (58.4%), and 4 cases were PD (33.3%). Adverse reactions included fever, fatigue, gastrointestinal reactions, hypothyroidism, and interstitial pneumonia. PD\u20101 monoclonal antibody immunotherapy had a certain short\u2010term effect on lymphoma.<\/jats:p>","DOI":"10.1155\/2022\/1388517","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T19:05:15Z","timestamp":1661972715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Short\u2010Term Efficacy of PD\u20101 Monoclonal Antibody Immunotherapy for Lymphoma by Positron Emission Tomography\/Computed Tomography Imaging with Convolutional Neural Network Image Registration Algorithm"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jie","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-3985","authenticated-orcid":false,"given":"Zhendong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_1_2","DOI":"10.1016\/j.jtho.2020.01.017"},{"doi-asserted-by":"publisher","key":"e_1_2_8_2_2","DOI":"10.1038\/s41392-020-00331-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_2","DOI":"10.1016\/S1470-2045(21)00097-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_2","DOI":"10.3760\/cma.j.cn112137-20201207-03281"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_2","DOI":"10.1186\/s40644-021-00381-y"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_2","DOI":"10.1186\/s40425-016-0166-5"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_2","DOI":"10.1007\/s11307-020-01558-w"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_2","DOI":"10.1002\/ajh.25154"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_2","DOI":"10.1097\/00041327-200109000-00004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_2","DOI":"10.1001\/jamaophthalmol.2019.0284"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_2","DOI":"10.1007\/s00262-021-02875-x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_2","DOI":"10.7150\/thno.61459"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_2","DOI":"10.1177\/1078155220985589"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_2","DOI":"10.1186\/s13014-021-01795-5"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_2","DOI":"10.1016\/j.cpet.2019.08.008"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_2","DOI":"10.1007\/s00259-017-3806-1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_2","DOI":"10.3389\/fonc.2021.728040"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_2","DOI":"10.2174\/1381612825666190829150302"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_2","DOI":"10.1016\/j.cryobiol.2018.04.013"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_2","DOI":"10.1038\/s41598-019-40748-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_2","DOI":"10.1038\/s41698-020-00135-2"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_2","DOI":"10.3389\/fonc.2021.769272"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_2","DOI":"10.1111\/bjd.14632"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_2","DOI":"10.1177\/2040620720902911"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_2","DOI":"10.1186\/s13569-016-0064-0"}],"container-title":["Contrast Media &amp; 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