{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:03:41Z","timestamp":1790730221974,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Provincial Association of Endemic Diseases","award":["X202107"],"award-info":[{"award-number":["X202107"]}]},{"name":"Key Specialty Discipline of Kunshan City","award":["X202107"],"award-info":[{"award-number":["X202107"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2022,10,21]]},"abstract":"<jats:p>Schistosomiasis remains a major global public health concern. Currently, the control of this neglected tropical disease still depends on chemotherapy to reduce the prevalence and intensity of the parasite infection. It has been widely accepted that praziquantel is highly effective against all species of Schistosoma, and this agent is virtually the only drug of choice for the treatment of human schistosomiasis. Mass drug administration (MDA) with praziquantel has been shown to be effective in greatly reducing the prevalence and morbidity due to schistosomiasis worldwide. In addition to antischistosomal activity, a large number of experiential and clinical evidence has demonstrated the action of praziquantel against fibrosis caused by S. mansoni and S. japonicum infections through decreasing the expression of fibrotic biomarkers such as \u03b1-smooth muscle actin (\u03b1-SMA), collagen, matrix metalloproteinase (MMP), and tissue inhibitor of metalloproteinase (TIMP), and inhibiting the expression of proinflammatory cytokines such as interleukin (IL)-6, tumor necrosis factor (TNF)-\u03b1, and transforming growth factor (TGF)-\u03b2, as well as chemokines, and similar antifibrotic activity was observed in mouse models of fibrosis induced by carbon tetrachloride (CCl4) and concanavalin A (Con-A). In this review, we discuss the role of praziquantel in the prevention and treatment of fibrosis associated with schistosomiasis and the possible mechanisms. We call for randomized, controlled clinical trials to evaluate the efficacy and safety of praziquantel in the treatment of schistosomiasis-induced hepatic fibrosis, and further studies to investigate the potential of praziquantel against fibrosis associated with alcohol consumption, viruses, and toxins seem justified.<\/jats:p>","DOI":"10.1155\/2022\/1413711","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T18:21:26Z","timestamp":1666376486000},"page":"1-8","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Praziquantel in the Prevention and Treatment of Fibrosis Associated with Schistosomiasis: A Review"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-7761","authenticated-orcid":true,"given":"Xuehua","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Kunshan Third People\u2019s Hospital, Kunshan 215300, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kunshan Third People\u2019s Hospital, Kunshan 215300, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kunshan Third People\u2019s Hospital, Kunshan 215300, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kunshan Third People\u2019s Hospital, Kunshan 215300, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhou","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kunshan Third People\u2019s Hospital, Kunshan 215300, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1812165"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-021-00863-y"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(19)30271-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2018058"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(21)00090-6"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.846108"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2021-005456"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01157.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.02.005"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14940"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155203"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"issue":"4","key":"14","first-page":"357","article-title":"The role of TGFbeta1 and IL-13 in cellular signal transduction of hepatic fibrosis of schistosomiasis","volume":"27","author":"J. 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