{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:22:01Z","timestamp":1770538921097,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TURSP-2020\/311"],"award-info":[{"award-number":["TURSP-2020\/311"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational Intelligence and Neuroscience"],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:p>To see if HHV-6 may be a cause of infertility, researchers looked at 18 men and 10 women who had unexplained critical fertility and had at least one prior pregnancy. HHV-6 DNA was discovered in both infertile and fertile peripheral blood mononuclear cells (PBMC) (12 and 14%, respectively); endometrial epithelial cells from 4\/10 (40%) infertile women were positive for HHV-6 DNA; this viral DNA was not found in the endometrium of fertile women. When endometrial epithelial cells were cultivated, they produced viral early and late proteins, suggesting the existence of an infectious virus. Endometrial HHV-6 infection creates an aberrant NK cell and cytokine profile, resulting in a uterine domain that is not favorable to conception, according to the findings. To corroborate the findings, studies of extra fertile and barren women should be done. Semen samples were taken from 18 guys who visited the Government General Hospital Guntur\u2019s infertility department because they were having reproductive issues with their partners. Herpes virus DNA has been discovered in the sperm of symptomatic fertile and infertile male patients on rare instances. Furthermore, researchers must investigate the role of viral diseases in male infertility.<\/jats:p>","DOI":"10.1155\/2022\/1422963","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T04:50:09Z","timestamp":1641617409000},"page":"1-5","source":"Crossref","is-referenced-by-count":31,"title":["Advanced Deep Learning Human Herpes Virus 6 (HHV-6) Molecular Detection in Understanding Human Infertility"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-1051","authenticated-orcid":true,"given":"Malik Bader","family":"Alazzam","sequence":"first","affiliation":[{"name":"Faculty of Computer Science and Informatics, Amman Arab University, Amman, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4531-8998","authenticated-orcid":true,"given":"Ahmad Tawfig","family":"Al-Radaideh","sequence":"additional","affiliation":[{"name":"Department of MIS, College of Business, Jadara University, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8617-2270","authenticated-orcid":true,"given":"Nasser","family":"Binsaif","sequence":"additional","affiliation":[{"name":"Department of E-Commerce, College of Administrative and Financial Sciences, Saudi Electronic University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-7600","authenticated-orcid":true,"given":"Ahmed S.","family":"AlGhamdi","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Collage of Computers and Information Technology, Taif University, P.O. 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