{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:44:36Z","timestamp":1788551076905,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":86,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Province Agricultural Industry Technology","award":["SDAIT-11-08"],"award-info":[{"award-number":["SDAIT-11-08"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>To investigate the change in zinc homeostasis of broilers under heat stress, 512 broiler chickens were raised to the age of 28 days. The broilers were then assigned to heat stress and normal temperature (36.0\u00b0C vs. 26.0\u00b0C) groups for 7 days. The results showed that oxidative stress induced by high temperature had a negative effect on the growth performance of broilers. Heat stress altered zinc homeostasis and led to a redistribution of zinc in broilers, which was reflected in increased zinc concentrations in the jejunum, liver, and tibia. Upregulation of the expression of the zinc exporter <jats:italic>ZnT1<\/jats:italic> and importers <jats:italic>ZIP8<\/jats:italic> and <jats:italic>ZIP14<\/jats:italic> in the jejunum indicated that more zinc was absorbed and transported from the jejunum into the blood, while the liver increased its capacity to hold zinc through upregulation of metallothionein (<jats:italic>MT<\/jats:italic>) expression, which was achieved by reducing <jats:italic>ZnT1<\/jats:italic> expression and upregulating the expression of the importer <jats:italic>ZIP3<\/jats:italic>. The pathway was mediated by zinc transporters, but the capacity of <jats:italic>MT<\/jats:italic> to chelate and release zinc ions also played a crucial role. The mechanism of alterations in zinc homeostasis under heat stress was revealed by the changes in zinc transporters and <jats:italic>MT<\/jats:italic> levels in the intestine and liver. Heat stress also altered cecal microbial diversity and reduced the relative abundances of <jats:italic>Bilophila<\/jats:italic> and <jats:italic>Dialister<\/jats:italic>. In conclusion, broilers altered systemic zinc homeostasis through the regulation of zinc transporters and <jats:italic>MT<\/jats:italic> in the liver and jejunum to resist oxidative stress induced by high temperature.<\/jats:p>","DOI":"10.1155\/2022\/1427335","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T23:05:08Z","timestamp":1648508708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["High Temperature\u2010Induced Oxidative Stress Affects Systemic Zinc Homeostasis in Broilers by Regulating Zinc Transporters and Metallothionein in the Liver and 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