{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:48:08Z","timestamp":1791254888628,"version":"4.1.0"},"reference-count":111,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008549","name":"Shanxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:p>We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m6A-RNA methylation (epitranscriptomic) regulators (m6A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m6A-RMRs were upregulated; and most m6A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m6A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m6A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m6A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m6A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m6A-RMRs the most among viral infections; (6) proinflammatory oxPAPC modulated m6A-RMRs more than DAMP stimulation including LPS and oxLDL; (7) upregulated m6A-RMRs were more than downregulated m6A-RMRs in cancer types; five types of cancers upregulated \u226510 m6A-RMRs; (8) proinflammatory M1 macrophages upregulated seven m6A-RMRs; (9) 86% of m6A-RMRs were differentially expressed in the six clusters of CD4+Foxp3+ immunosuppressive Treg, and 8 out of 12 Treg signatures regulated m6A-RMRs; (10) immune checkpoint receptors TIM3, TIGIT, PD-L2, and CTLA4 modulated m6A-RMRs, and inhibition of CD40 upregulated m6A-RMRs; (11) cytokines and interferons modulated m6A-RMRs; (12) NF-\u03baB and JAK\/STAT pathways upregulated more than downregulated m6A-RMRs whereas TP53, PTEN, and APC did the opposite; (13) methionine-homocysteine-methyl cycle enzyme Mthfd1 downregulated more than upregulated m6A-RMRs; (14) m6A writer RBM15 and one m6A eraser FTO, H3K4 methyltransferase MLL1, and DNA methyltransferase, DNMT1, regulated m6A-RMRs; and (15) 40 out of 165 ROS regulators were modulated by m6A eraser FTO and two m6A writers METTL3 and WTAP. Our findings shed new light on the functions of upregulated m6A-RMRs in 41 diseases and cancers, nine cellular and molecular mechanisms, novel therapeutic targets for inflammatory disorders, metabolic cardiovascular diseases, autoimmune diseases, organ failures, and cancers.<\/jats:p>","DOI":"10.1155\/2022\/1433323","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T19:35:10Z","timestamp":1644953710000},"page":"1-42","source":"Crossref","is-referenced-by-count":33,"title":["29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation \u2013 102 Transcriptomic Dataset Analyses"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ming","family":"Liu","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"},{"name":"Department of Cell Biology and Genetics, School of Basic Medical Science, Shanxi Medical University, Taiyuan, Shanxi 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keman","family":"Xu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Saaoud","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shao","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"},{"name":"Department of Nephrology, The Affiliated People\u2019s Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Lu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"Charles","family":"Drummer","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics, School of Basic Medical Science, Shanxi Medical University, Taiyuan, Shanxi 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Metabolic Disease Research; Inflammation, Translational & Clinical Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya P.","family":"Kunapuli","sequence":"additional","affiliation":[{"name":"Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Criner","sequence":"additional","affiliation":[{"name":"Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Shan","sequence":"additional","affiliation":[{"name":"Metabolic Disease Research; Inflammation, Translational & Clinical Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"},{"name":"Metabolic Disease Research; Inflammation, Translational & Clinical Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Metabolic Disease Research; Inflammation, Translational & Clinical Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-6195","authenticated-orcid":true,"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"},{"name":"Metabolic Disease Research; Inflammation, Translational & Clinical Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"},{"name":"Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0106-z"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305282"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306964"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0809"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308501"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308750"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-016-9683-3"},{"key":"9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.2741\/4337","article-title":"Chronic kidney disease alters vascular smooth muscle cell phenotype","volume":"20","author":"M. A. Monroy","year":"2015","journal-title":"Frontiers in Bioscience"},{"key":"10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2741\/4595","article-title":"Uremic toxins are conditional danger- or homeostasis-associated molecular patterns","volume":"23","author":"Y. Sun","year":"2018","journal-title":"Frontiers in Bioscience"},{"issue":"12","key":"11","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1515\/CCLM.2007.350","article-title":"Hyperhomocysteinemia, DNA methylation and vascular disease","volume":"45","author":"M. S. Jamaluddin","year":"2007","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-5-66"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.08.001"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-015-9664-y"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310626"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315452"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314330"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.663286"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0080-6"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002752"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00433"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.641191"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081036"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313138"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.2741\/3217"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.07.041"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-015-0001-0"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-267989"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2741\/4383"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00516"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-6-19"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9110879"},{"key":"33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.abb.2018.12.002","article-title":"Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation - a novel concept","volume":"662","author":"G. K. Nanayakkara","year":"2019","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-55330-6_20"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1036"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx934"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105977"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-00295-8"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.01.001"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.50003"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-021-10108-w"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0231-8"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.680389"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.713170"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/S1476-5586(04)80047-2"},{"issue":"11","key":"46","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1164\/rccm.201201-0003OC","article-title":"Inflammasome-regulated cytokines are critical mediators of acute lung injury","volume":"185","author":"T. Dolinay","year":"2012","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa5993"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002102"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607028103"},{"issue":"10","key":"50","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"S. Zaccara","year":"2019","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"1","key":"51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrm.2016.132","article-title":"Post-transcriptional gene regulation by mRNA modifications","volume":"18","author":"B. S. Zhao","year":"2017","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.045"},{"issue":"6, article e1489","key":"53","article-title":"RNA methylation in nuclear pre-mRNA processing","volume":"9","author":"H. Covelo-Molares","year":"2018","journal-title":"Wiley Interdisciplinary Reviews: RNA"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00327"},{"issue":"1","key":"55","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13045-019-0805-7","article-title":"The interplay between m6A RNA methylation and noncoding RNA in cancer","volume":"12","author":"S. Ma","year":"2019","journal-title":"Journal of Hematology & Oncology"},{"issue":"5","key":"56","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/wrna.79","article-title":"RNA nucleotide methylation","volume":"2","author":"Y. Motorin","year":"2011","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"3","key":"57","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41591-020-0752-4","article-title":"An immune-cell signature of bacterial sepsis","volume":"26","author":"M. Reyes","year":"2020","journal-title":"Nature Medicine"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.739839"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01297"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.722728"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8813909"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.08.010"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00665-17"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069374"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01102-13"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310388"},{"issue":"12","key":"67","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1084\/jem.20150603","article-title":"Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis","volume":"212","author":"A. Briot","year":"2015","journal-title":"The Journal of Experimental Medicine"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00117.2011"},{"key":"69","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2741\/4127","article-title":"Inflammasomes: sensors of metabolic stresses for vascular inflammation","volume":"18","author":"Y. Yin","year":"2013","journal-title":"Frontiers in Bioscience"},{"issue":"2","key":"70","first-page":"125","article-title":"Vascular inflammation and atherogenesis are activated via receptors for PAMPs and suppressed by regulatory T cells","volume":"5","author":"X. F. Yang","year":"2008","journal-title":"Drug Discovery Today: Therapeutic Strategies"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301989"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038362"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2019.02.008"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai8478"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0501"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01512"},{"issue":"2","key":"78","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41573-020-00091-3","article-title":"Targeting Notch in oncology: the path forward","volume":"20","author":"S. Majumder","year":"2021","journal-title":"Nature Reviews. Drug Discovery"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.2741\/2775"},{"issue":"5","key":"80","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1074-7613(00)80384-2","article-title":"A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells","volume":"7","author":"X. F. Yang","year":"1997","journal-title":"Immunity"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00818"},{"issue":"7","key":"82","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-020-0352-5","article-title":"T cell subsets and functions in atherosclerosis","volume":"17","author":"R. Saigusa","year":"2020","journal-title":"Nature Reviews Cardiology"},{"issue":"12","key":"83","article-title":"Regulatory T cell stability and plasticity in atherosclerosis","volume":"9","author":"A. J. Ali","year":"2020","journal-title":"Cell"},{"key":"84","first-page":"3986","article-title":"Roles of CD4+CD25(high) FOXP3+ Tregs in lymphomas and tumors are complex","volume":"13","author":"X. Ke","year":"2008","journal-title":"Frontiers in Bioscience"},{"issue":"3","key":"85","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41590-018-0051-0","article-title":"Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR","volume":"19","author":"D. Zemmour","year":"2018","journal-title":"Nature Immunology"},{"key":"86","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2741\/4710","article-title":"Co-signaling receptors regulate T-cell plasticity and immune tolerance","volume":"24","author":"H. Shen","year":"2019","journal-title":"Frontiers in Bioscience"},{"issue":"7","key":"87","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/ni.2914","article-title":"CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype","volume":"15","author":"G. V. Zuccarino-Catania","year":"2014","journal-title":"Nature Immunology"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067799"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.052"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag0367"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.690081"},{"key":"92","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1756-8722-6-61","article-title":"An evolving new paradigm: endothelial cells--conditional innate immune cells","volume":"6","author":"J. Mai","year":"2013","journal-title":"Journal of Hematology & Oncology"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.2741\/3657"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.06.003"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033628"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.460626"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-162"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.269472"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.866889"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000242559.42077.22"},{"issue":"12","key":"101","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1515\/CCLM.2007.358","article-title":"Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular disease","volume":"45","author":"D. Liao","year":"2007","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"issue":"10","key":"102","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1182\/blood-2002-08-2606","article-title":"Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation","volume":"101","author":"H. Wang","year":"2003","journal-title":"Blood"},{"issue":"12","key":"103","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/nsmb.1961","article-title":"The histone methyltransferase MLL1 permits the oscillation of circadian gene expression","volume":"17","author":"S. Katada","year":"2010","journal-title":"Nature Structural & Molecular Biology"},{"issue":"3","key":"104","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1139\/cjpp-2016-0515","article-title":"Mitochondrial ROS, uncoupled from ATP synthesis, determine endothelial activation for both physiological recruitment of patrolling cells and pathological recruitment of inflammatory cells","volume":"95","author":"X. Li","year":"2017","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1080"},{"issue":"11","key":"106","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41568-019-0187-8","article-title":"Methionine metabolism in health and cancer: a nexus of diet and precision medicine","volume":"19","author":"S. M. Sanderson","year":"2019","journal-title":"Nature Reviews Cancer"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0143-1"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00946-x"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.06.060"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.017"},{"key":"111","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12865-015-0113-0","article-title":"Immune cell subsets and their gene expression profiles from human PBMC isolated by Vacutainer Cell Preparation Tube (CPT) and standard density gradient","volume":"16","author":"C. P. Corkum","year":"2015","journal-title":"BMC Immunology"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/1433323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/1433323.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/1433323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T19:35:35Z","timestamp":1644953735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2022\/1433323\/"}},"subtitle":[],"editor":[{"given":"Baohui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":111,"alternative-id":["1433323","1433323"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1433323","relation":{},"ISSN":["2314-7156","2314-8861"],"issn-type":[{"value":"2314-7156","type":"electronic"},{"value":"2314-8861","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,15]]}}}