{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:42:48Z","timestamp":1782776568062,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,5]]},"abstract":"<jats:p>Objective. To assess the effectiveness of laparoscopic cholecystectomy in patients with gallbladder stones and chronic cholecystitis. Methods. From July 2018 to January 2020, 90 patients with gallbladder stones and chronic cholecystitis assessed for eligibility were recruited and concurrently assigned (1\u2009:\u20091) to receive either small-incision cholecystectomy (observation group) or laparoscopic cholecystectomy (experimental group). Outcome measures included operation time, intraoperative bleeding volume, postoperative hospital stay, c-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-\u03b1 (TNF-\u03b1), gastrin (GAS), vasoactive intestinal peptide (VIP), motilin (MOT), and adverse events. Results. Patients given laparoscopic cholecystectomy showed lower levels of operation-related indices versus those receiving small-incision cholecystectomy (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Laparoscopic cholecystectomy resulted in lower postoperative levels of CRP, IL-6, and TNF-\u03b1 in the patients versus small-incision cholecystectomy (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Patients receiving laparoscopic cholecystectomy showed better GAS, VIP, and MOT levels than those receiving small-incision cholecystectomy (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). The eligible patients after laparoscopic cholecystectomy had a significantly lower incidence of adverse events versus those after small-incision cholecystectomy (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conclusion. Laparoscopic cholecystectomy effectively shortens the operative time and length of hospital stay in patients with gallbladder stones and chronic cholecystitis, reduces intraoperative bleeding, attenuates the inflammatory response, and enhances the gastrointestinal function, with less surgical trauma and high safety. Clinical trials are, however, required prior to promotion.<\/jats:p>","DOI":"10.1155\/2022\/1434410","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T20:35:08Z","timestamp":1659731708000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of Laparoscopic Cholecystectomy in Patients with Gallbladder Stones with Chronic Cholecystitis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Leiping","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Jinshan Branch of Shanghai the Sixth People\u2019s Hospital, Shanghai 201599, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Jinshan Branch of Shanghai the Sixth People\u2019s Hospital, Shanghai 201599, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Jinshan Branch of Shanghai the Sixth People\u2019s Hospital, Shanghai 201599, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Jinshan Branch of Shanghai the Sixth People\u2019s Hospital, Shanghai 201599, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Jinshan Branch of Shanghai the Sixth People\u2019s Hospital, Shanghai 201599, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-213X","authenticated-orcid":true,"given":"Qiyun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Jinshan Branch of Shanghai the Sixth People\u2019s Hospital, Shanghai 201599, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1553184"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-226402"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4371-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17207571"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.517"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.17116\/hirurgia201902132"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.11.006"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010507.pub2"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15314"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.17116\/hirurgia2017397-101"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0376-2491.2016.46.005"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5061-0"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.5009\/gnl20052"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000026885"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.03.004"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.06.023"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.21614\/chirurgia.115.2.208"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-06613-w"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17021"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.616"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.2478\/prilozi-2019-0018"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3390\/pediatric13030054"},{"issue":"10","key":"23","article-title":"Endogenic antimicrobial peptides and cytokines in calculous cholecystitis","author":"J. 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