{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:59:16Z","timestamp":1771232356851,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1K99CA256216"],"award-info":[{"award-number":["1K99CA256216"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/NCI Cancer Center Support","award":["1K99CA256216"],"award-info":[{"award-number":["1K99CA256216"]}]},{"name":"NIH\/NCI Cancer Center Support","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2022,12,31]]},"abstract":"<jats:p>Background. Patients with unilateral breast cancer carrying pathogenic variants in BRCA1\/2 have the option to undergo contralateral prophylactic mastectomy (CPM). However, differences in CPM use and survival outcomes following CPM are poorly understood in this high-risk population, in part due to a lack of data from contemporary clinical cohorts. The objective of this study was to evaluate post-CPM overall survival (OS) and related racial\/ethnic differences in a contemporary clinical cohort. Methods. We retrospectively reviewed the medical records of women with a personal history of unilateral breast cancer carrying pathogenic variants in BRCA1\/2 who were diagnosed between 1996 and 2012. Genetic test results, self-reported demographic characteristics, and clinical factors were abstracted from electronic medical records. Results. Of 144 BRCA-positive patients, the majority were White (79.2%, n\u2009=\u2009114). Overall, 56.1% (n\u2009=\u200981) of all BRCA1\/2 carriers chose to undergo CPM, with no racial\/ethnic difference in CPM election (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009=\u20090.78). Of 81 patients who underwent CPM, there is strong evidence of a difference in survival between the racial\/ethnic groups, with White patients having the highest OS compared to non-White patients (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009=\u20090.001). Of the 63 patients who did not undergo CPM, there is no racial\/ethnic difference in overall survival (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009=\u20090.61). In multivariable cox regression, adjusted for demographic and clinical characteristics, OS was significantly lower among non-Whites than in Whites (HR\u2009=\u20090.39, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009=\u20090.04). Conclusions. Evaluation of a contemporary clinical cohort of BRCA-positive women with unilateral breast cancer showed no racial\/ethnic difference in CPM use, but there was a significant difference in post-CPM overall survival.<\/jats:p>","DOI":"10.1155\/2022\/1447545","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:35:10Z","timestamp":1672533310000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Contralateral Prophylactic Mastectomy among Women with Pathogenic Variants in BRCA1\/2: Overall Survival, Racial, and Ethnic Differences"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-3833","authenticated-orcid":true,"given":"Sukh","family":"Makhnoon","sequence":"first","affiliation":[{"name":"Department of Behavioral Science, UT MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8582-8186","authenticated-orcid":true,"given":"Angelica M.","family":"Gutierrez Barrera","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology Research, UT MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-2042","authenticated-orcid":true,"given":"Roland","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, UT MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimaz","family":"Afrough","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology\/Oncology, UT Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-8361","authenticated-orcid":true,"given":"Isabelle","family":"Bedrosian","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5475-8509","authenticated-orcid":true,"given":"Banu K.","family":"Arun","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology Research, UT MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5443-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt095"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.00299"},{"issue":"9","key":"4","article-title":"Differences in physician opinions about controversial issues surrounding contralateral prophylactic mastectomy (cpm): a survey of physicians from accredited breast centers in the United States","volume":"9","author":"K. Yao","year":"2020","journal-title":"Cancer Medicine"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000001698"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.10.080"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g226"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9610(00)00505-5"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.20.1681"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000000769"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd002748.pub3"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3160-y"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3930-0"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602703"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29032"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2583-1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2004.04.086"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-019-05515-2"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-017-0004-z"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08889-6"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2016.02.011"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1434-0"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.capr-09-0130"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.epi-09-0171"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju160"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1091-3"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33501"}],"container-title":["The Breast Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tbj\/2022\/1447545.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tbj\/2022\/1447545.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tbj\/2022\/1447545.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:35:15Z","timestamp":1672533315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/tbj\/2022\/1447545\/"}},"subtitle":[],"editor":[{"given":"Anjali","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,31]]},"references-count":27,"alternative-id":["1447545","1447545"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1447545","relation":{},"ISSN":["1524-4741","1075-122X"],"issn-type":[{"value":"1524-4741","type":"electronic"},{"value":"1075-122X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,31]]}}}