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Acne perturbs up to 85% of adolescents, while it is periodically misconceived as an ailment that affects teenagers only; nonetheless, it also affects myriad adults. Acne has well\u2010documented psychosocial ramifications, including adverse effects on self\u2010perception, mental health, and social functioning. Trifarotene is basically a novel fourth\u2010generation locally applied retinoid approved for the first time in the regimens of both face and truncal acnes. The exclusive topical retinoid that adheres precisely to RAR\u2010gamma, the epidermis' most frequent isoform, is trifarotene, approved in October 2019. The current review evaluates the role of trifarotene in treating acne.<\/jats:p>","DOI":"10.1155\/2022\/1504303","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T13:35:08Z","timestamp":1653658508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Trifarotene: A Novel Therapeutic Option for Acne"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-4062","authenticated-orcid":false,"given":"Piyu Parth","family":"Naik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.34-11-479"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.4.454"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62715-3"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0558-5"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0926-9959.2001.00006.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.1390s2003.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S286953"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.044"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9030237"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2017.03.003"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb05757.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1989.tb00930.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.07175.x"},{"key":"e_1_2_7_16_2","unstructured":"DeRuiterJ.andHolstonP. 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