{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:37:24Z","timestamp":1775068644896,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2022,1,19]]},"abstract":"<jats:p>The current research approaches the retinal microvasculature of healthy volunteers (17 subjects), patients with diabetes mellitus without retinopathy (19 subjects), and of diabetic patients with nonproliferative (17 subjects) and proliferative (21 subjects) diabetic retinopathy, by using adaptive optics ophthalmoscopy and optical coherence ophthalmoscopy angiography. For each imaging technique, several vascular parameters have been calculated in order to achieve a comparative analysis of these imaging biomarkers between the four studied groups. The results suggest that diabetic patients with or without diabetic retinopathy prove signs of retinal arteriole structural alterations, mainly showed by altered values of wall to lumen ratio, calculated for the superior or inferior temporal branch of the central retinal artery, near the optic nerve head, and significant changes of the vascular density in the retinal superficial capillary plexus. Both adaptive optics ophthalmoscopy and optical coherence ophthalmoscopy angiography are providing useful information about the retinal microvasculature from early onset of diabetic disease, having a promising diagnostic and prognostic role in the future.<\/jats:p>","DOI":"10.1155\/2022\/1516668","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:51:16Z","timestamp":1642639876000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence Angiography"],"prefix":"10.1155","volume":"2022","author":[{"given":"Florian","family":"Balt\u0103","sequence":"first","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Clinical Emergency Eye Hospital, 030167 Bucharest, Romania"},{"name":"\u201cRetina\u201d Clinic, 014142 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-077X","authenticated-orcid":true,"given":"Irina-Elena","family":"Cristescu","sequence":"additional","affiliation":[{"name":"\u201cRetina\u201d Clinic, 014142 Bucharest, Romania"},{"name":"Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrada-Elena","family":"Mirescu","sequence":"additional","affiliation":[{"name":"Clinical Emergency Eye Hospital, 030167 Bucharest, Romania"},{"name":"Department of Ophthalmology, \u201cOvidius\u201d University of Medicine, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Balt\u0103","sequence":"additional","affiliation":[{"name":"Clinical Emergency Eye Hospital, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihail","family":"Zemba","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Ophthalmology, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010825 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8235-4501","authenticated-orcid":true,"given":"Ioana Teodora","family":"Tofolean","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"\u201cRetina\u201d Clinic, 014142 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4960852"},{"key":"2","article-title":"Diabetic retinopathy","volume-title":"StatPearls","author":"U. 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