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We aimed to compare outcome of two types of combination therapies atazanavir\/ritonavir (ATV\/r) or lopinavir\/ritonavir (LPV\/r) plus hydroxychloroquine among COVID\u201019 patients. 108 patients with moderate and severe forms of COVID\u201019 were divided into two groups (each group 54 patients). One group received ATV\/r plus hydroxychloroquine, and the other group received hydroxychloroquine plus LPV\/r. Then, both groups were evaluated and compared for clinical symptoms, recovery rates, and complications of treatment regimens. Our findings showed a significant increase in bilirubin in ATV\/r\u2010receiving group compared to LPV\/r receivers. There was also a significant increase in arrhythmias in the LPV\/r group compared to the ATV\/r group during treatment. Other findings including length of hospital stay, outcome, and treatment complications were not statistically significant. There is no significant difference between protease inhibitor drugs including ATV\/r and LPV\/r in the treatment of COVID\u201019 regarding clinical outcomes. However, some side effects such as hyperbilirubinemia and arrhythmia were significantly different by application of atazanavir or lopinavir.<\/jats:p>","DOI":"10.1155\/2022\/1522426","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T16:05:36Z","timestamp":1641571536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparing Outcomes of Two Antiviral Therapy Combinations among COVID\u201019 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