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The structural and physicochemical features of the P(VCL\u2010co\u2010AA) nanogel were characterized by FT\u2010IR, DLS\/Zeta potential, FE\u2010SEM, and <jats:sup>1<\/jats:sup>HNMR techniques. The results indicated that spherical polymeric nanogel was successfully synthesized with a 182\u2009nm diameter. The results showed that the polymerization process continues with the opening of the carbon\u2010carbon double bond of monomers, which was approved by C\u2010C band removing located at 1600\u2009cm<jats:sup>-1<\/jats:sup>. Doxorubicin (Dox) as a chemotherapeutic agent was loaded into the P(VCL\u2010co\u2010AA), whit a significant loading of Dox (83%), and the drug release profile was investigated in the physiological and cancerous site simulated conditions. P(VCL\u2010co\u2010AA) exhibited a pH and temperature\u2010responsive behavior, with an enhanced release rate in the cancerous site condition. The biocompatibility and nontoxicity of P(VCL\u2010co\u2010AA) were approved by MTT assay on the normal human foreskin fibroblasts\u20102 (HFF\u20102) cell line. Also, Dox\u2010loaded P(VCL\u2010co\u2010AA) had excellent toxic behavior on the Michigan Cancer Foundation\u20107 (MCF\u20107) cell line as model cancerous cells. 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