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The persistence of pain, impairment of cognitive function, and negative impact on the psychological state have caused a detrimental effect on the patients\u2019 quality of life. However, to date, the treatment and mechanisms of this disease are yet to be established. Oxidative stress might play a critical role in FM pathophysiology. Increased levels of prooxidative factors such as nitric oxide, lipid peroxidation, and mitophagy can cause pain sensitization in fibromyalgia. Numerous studies have supported the hypothesis of beneficial antioxidative effects in FM. Due to the lack of effective therapy for fibromyalgia, many treatments are sought to reduce pain and fatigue and improve patients\u2019 quality of life. This manuscript discusses the impact of various antioxidative procedures that can diminish fibromyalgia symptoms, such as hyperbaric oxygen therapy, modification of dietary habits, and physical activity.<\/jats:p>","DOI":"10.1155\/2022\/1582432","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T17:35:06Z","timestamp":1664991306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Oxidative Stress in Fibromyalgia: From Pathology to Treatment"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5135-7347","authenticated-orcid":false,"given":"Chanika","family":"Assavarittirong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-894X","authenticated-orcid":false,"given":"W\u0142odzimierz","family":"Samborski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-0764","authenticated-orcid":false,"given":"Bogna","family":"Grygiel-G\u00f3rniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20140"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083891"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01638.x"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcle.2017.10.011"},{"key":"e_1_2_12_6_2","first-page":"295","article-title":"Fibromyalgia and psychiatric comorbidity: their effect on the quality of life patients","volume":"38","author":"Gonz\u00e1lez E.","year":"2010","journal-title":"Actas Espa\u00f1olas de Psiquiatr\u00eda"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10880-021-09832-x"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-8-199304150-00009"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/918216"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217877"},{"key":"e_1_2_12_11_2","first-page":"169","article-title":"Oxidative stress and mitochondrial dysfunction in fibromyalgia","volume":"31","author":"Cordero M. 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