{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:50:17Z","timestamp":1772164217037,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2019YFC0120600"],"award-info":[{"award-number":["2019YFC0120600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2041ZF260"],"award-info":[{"award-number":["2041ZF260"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014882","name":"Department of Finance of Hebei","doi-asserted-by":"publisher","award":["2019YFC0120600"],"award-info":[{"award-number":["2019YFC0120600"]}],"id":[{"id":"10.13039\/501100014882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014882","name":"Department of Finance of Hebei","doi-asserted-by":"publisher","award":["2041ZF260"],"award-info":[{"award-number":["2041ZF260"]}],"id":[{"id":"10.13039\/501100014882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011494","name":"Baoding City Science and Technology and Intellectual Property Bureau","doi-asserted-by":"publisher","award":["2019YFC0120600"],"award-info":[{"award-number":["2019YFC0120600"]}],"id":[{"id":"10.13039\/501100011494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011494","name":"Baoding City Science and Technology and Intellectual Property Bureau","doi-asserted-by":"publisher","award":["2041ZF260"],"award-info":[{"award-number":["2041ZF260"]}],"id":[{"id":"10.13039\/501100011494","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2022,4,13]]},"abstract":"<jats:p>\n                    We aimed to investigate whether the use of intravenous paracetamol (IVP) preoperatively in intertrochanteric fracture (IF) patients aged 65 years or over receiving intramedullary fixation had significantly benefits on the pain score at discharge, delirium incidence, length of hospital stay (LOS), functional outcomes, and mortality. A retrospective analysis of all surgically treated patients presenting with IF was conducted at a single Level I trauma center in China between Jan. 2016 and Jan. 2020. The data concerning patients\u2019 demographics, injury-related data, surgery-related data, operation-related data, in-hospital data, and postoperative outcomes were extracted. To minimize potential confounding and selection bias, the propensity score matching (PSM) method was performed via the caliper matching method by using a 1\u2009:\u20091 ratio. After PSM, McNemar\u2019s chi-square tests were used to examine the association of using IVP with outcome analyses. The Spearman correlations of IVP using, pain scores, and the factors which may influence them were also computed. After screening 2963 consecutive patients, 2166 were included finally, including 1576 in the non-IVP group and 590 in the IVP group. After PSM, 531 remained in each group. The pain scores at discharge were significantly between the two groups before and after matching (all\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The differences of delirium rate and functional outcomes became significant after propensity score-based matching (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    and 0.033, respectively), although they were not significant before matching. No significant difference was observed in other operation-related data, LOS, and crude mortality rates at 30-day, 90-day, and 12-month before and after PSM. In conclusion, this study highlights the need for preoperative IVP use to optimize pain control, postoperative functional recovery, and minimize pain-related comorbidities such as delirium in elderly patients with hip fracture.\n                  <\/jats:p>","DOI":"10.1155\/2022\/1582727","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T20:50:06Z","timestamp":1649883006000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Use of Intravenous Paracetamol Preoperatively Favors Lower Risk of Delirium and Functional Recovery in Elderly Patients with Hip Fracture: A Propensity Score-Matched Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-3885","authenticated-orcid":true,"given":"Junfei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China"},{"name":"Orthopaedic Institute of Hebei Province, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0465-586X","authenticated-orcid":true,"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China"},{"name":"Orthopaedic Institute of Hebei Province, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-826X","authenticated-orcid":true,"given":"Xuehong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Hebei General Hospital, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-4916","authenticated-orcid":true,"given":"Yubin","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Baoding First Central Hospital, Baoding, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1804-4573","authenticated-orcid":true,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China"},{"name":"Orthopaedic Institute of Hebei Province, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-1607","authenticated-orcid":true,"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Children\u2019s Hospital of Hebei Affiliated to Hebei Medical University, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-3262","authenticated-orcid":true,"given":"Junchuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China"},{"name":"Orthopaedic Institute of Hebei Province, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-6883","authenticated-orcid":true,"given":"Guolei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China"},{"name":"Orthopaedic Institute of Hebei Province, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9846-4799","authenticated-orcid":true,"given":"Junpu","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China"},{"name":"Orthopaedic Institute of Hebei Province, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-4025","authenticated-orcid":true,"given":"Zhiyong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China"},{"name":"Orthopaedic Institute of Hebei Province, Shijiazhuang, China"},{"name":"NHC Key Laboratory of Intelligent Orthopeadic Equipment, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4355-2238","authenticated-orcid":true,"given":"Yingze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China"},{"name":"Orthopaedic Institute of Hebei Province, Shijiazhuang, China"},{"name":"NHC Key Laboratory of Intelligent Orthopeadic Equipment, Shijiazhuang, China"},{"name":"Chinese Academy of Engineering, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16162847"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3822"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2017.03.003"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2013.878831"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1401-4"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1462"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00813-5"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/sni.sni_301_17"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(02)00458-x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12299"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb06644.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009984.pub3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/273783"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013383"},{"issue":"1","key":"15","first-page":"2","article-title":"Analgesia after hip fracture repair in elderly patients: the effect of a continuous femoral nerve block: a prospective and randomised study","volume":"26","author":"P. Cuvillon","year":"2007","journal-title":"Annales Fran\u00e7aises d\u2019Anesthesie et de Reanimation"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1177\/2151458515588560"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1177\/0310057x1103900214"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28621-5"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2021.34.3.271"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0524-6"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-018-0379-2"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2010.00991.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.4.378"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90097-3"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1159\/000519510"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1159\/000515526"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/gps.880"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8814290"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1177\/2151459318806443"},{"issue":"6","key":"30","first-page":"514","article-title":"Is the WHO analgesic ladder still valid? Twenty-four years of experience","volume":"56","author":"G. Vargas-Schaffer","year":"2010","journal-title":"Canadian Family Physician"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200203000-00019"},{"issue":"6","key":"32","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/00000539-200106000-00024","article-title":"Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery","volume":"92","author":"J. Hern\u00e1ndez-Palaz\u00f3n","year":"2001","journal-title":"Anesthesia & Analgesia"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb04919.x"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20130122-53"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9432493"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0b013e3181aae87a"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.s156104"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.01.011"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1097\/bot.0b013e318191f5e4"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2022\/1582727.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2022\/1582727.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2022\/1582727.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T20:50:10Z","timestamp":1649883010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/prm\/2022\/1582727\/"}},"subtitle":[],"editor":[{"given":"Xiaolong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,13]]},"references-count":39,"alternative-id":["1582727","1582727"],"URL":"https:\/\/doi.org\/10.1155\/2022\/1582727","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742076107.793593424","asserted-by":"object"}]},"ISSN":["1918-1523","1203-6765"],"issn-type":[{"value":"1918-1523","type":"electronic"},{"value":"1203-6765","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,13]]}}}